The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study

A. J.C. Slooter; M. Cruts; A. Hofman; P. J. Koudstaal; D. Van Der Kuip; M. A.J. De Ridder; J. C.M. Witteman; M. M.B. Breteler; C. Van Broeckhoven; Cornelia M. Van Duijn

doi:10.1212/01.WNL.0000118302.66674.E1

The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study

A. J.C. Slooter, M. Cruts, A. Hofman, P. J. Koudstaal, D. Van Der Kuip, M. A.J. De Ridder, J. C.M. Witteman, M. M.B. Breteler, C. Van Broeckhoven, Cornelia M. Van Duijn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

40 Citations (Scopus)

Abstract

It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of ε4, the incidence of dementia would be 25.8% lower; in the absence of ε2/ε3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

Original language	English
Pages (from-to)	1196-1198
Number of pages	3
Journal	Neurology
Volume	62
Issue number	7
DOIs	https://doi.org/10.1212/01.WNL.0000118302.66674.E1
Publication status	Published - 13 Apr 2004
Externally published	Yes

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title = "The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study",

abstract = "It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of ε4, the incidence of dementia would be 25.8% lower; in the absence of ε2/ε3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.",

author = "Slooter, {A. J.C.} and M. Cruts and A. Hofman and Koudstaal, {P. J.} and {Van Der Kuip}, D. and {De Ridder}, {M. A.J.} and Witteman, {J. C.M.} and Breteler, {M. M.B.} and {Van Broeckhoven}, C. and {Van Duijn}, {Cornelia M.}",

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AU - Slooter, A. J.C.

AU - Cruts, M.

AU - Hofman, A.

AU - Koudstaal, P. J.

AU - Van Der Kuip, D.

AU - De Ridder, M. A.J.

AU - Witteman, J. C.M.

AU - Breteler, M. M.B.

AU - Van Broeckhoven, C.

AU - Van Duijn, Cornelia M.

PY - 2004/4/13

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AB - It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of ε4, the incidence of dementia would be 25.8% lower; in the absence of ε2/ε3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.

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The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study

Abstract

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