The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

Cornelis H. van Werkhoven; Susanne M Huijts; M Bolkenbaas; Diederick E Grobbee; Marc J M Bonten

doi:10.1093/cid/civ686

The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

Cornelis H. van Werkhoven, Susanne M Huijts, M Bolkenbaas, Diederick E Grobbee, Marc J M Bonten

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.

Original language	English
Pages (from-to)	1835-1838
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	61
Issue number	12
DOIs	https://doi.org/10.1093/cid/civ686
Publication status	Published - 15 Dec 2015

Keywords

pneumococcal conjugate vaccine
community-acquired pneumonia
invasive pneumococcal disease
vaccine efficacy
immunosenescence

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10.1093/cid/civ686

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title = "The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly",

abstract = "In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.",

keywords = "pneumococcal conjugate vaccine, community-acquired pneumonia, invasive pneumococcal disease, vaccine efficacy, immunosenescence",

author = "{van Werkhoven}, {Cornelis H.} and Huijts, {Susanne M} and M Bolkenbaas and Grobbee, {Diederick E} and Bonten, {Marc J M}",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].",

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AU - Grobbee, Diederick E

AU - Bonten, Marc J M

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AB - In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.

KW - pneumococcal conjugate vaccine

KW - community-acquired pneumonia

KW - invasive pneumococcal disease

KW - vaccine efficacy

KW - immunosenescence

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The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

Abstract

Keywords

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