The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W. Brands; H. Leland Mizelle; Carlo A. Gaillard; Drew A. Hildebrandt; John E. Hall

doi:10.1093/ajh/4.2.164

The hemodynamic response to chronic hyperinsulinemia in conscious dogs

Michael W. Brands^*
, H. Leland Mizelle
, Carlo A. Gaillard
, Drew A. Hildebrandt
, John E. Hall

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

80 Citations (Scopus)

Abstract

This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect. © 1991 by the American Journal of Hypertension, Inc.

Original language	English
Pages (from-to)	164-168
Number of pages	5
Journal	American Journal of Hypertension
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/ajh/4.2.164
Publication status	Published - 1991
Externally published	Yes

Keywords

Animals Blood Glucose/metabolism Blood Volume/drug effects Cardiac Output/drug effects Consciousness Dogs Hemodynamics/*drug effects Infusions, Intravenous Insulin/administration & dosage/*blood/pharmacology Sodium/urine Vascular Resistance/drug effects Water-Electrolyte Balance/drug effects

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10.1093/ajh/4.2.164

http://www.ncbi.nlm.nih.gov/pubmed/2021447

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title = "The hemodynamic response to chronic hyperinsulinemia in conscious dogs",

abstract = "This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8\% above control by day 7. Total peripheral resistance decreased to 69 ± 5\% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22\% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect. {\textcopyright} 1991 by the American Journal of Hypertension, Inc.",

keywords = "Animals Blood Glucose/metabolism Blood Volume/drug effects Cardiac Output/drug effects Consciousness Dogs Hemodynamics/*drug effects Infusions, Intravenous Insulin/administration \& dosage/*blood/pharmacology Sodium/urine Vascular Resistance/drug effects Water-Electrolyte Balance/drug effects",

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doi = "10.1093/ajh/4.2.164",

language = "English",

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AU - Leland Mizelle, H.

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AU - Hildebrandt, Drew A.

AU - Hall, John E.

N1 - M1 - 2 Pt 1 Brands, M W Mizelle, H L Gaillard, C A Hildebrandt, D A Hall, J E HL11678/HL/NHLBI NIH HHS/ HL23502/HL/NHLBI NIH HHS/ HL39399/HL/NHLBI NIH HHS/ etc. Am J Hypertens. 1991 Feb;4(2 Pt 1):164-8.

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N2 - This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect. © 1991 by the American Journal of Hypertension, Inc.

AB - This study describes the hemodynamic effects of chronic hyperinsulinemia in seven normal dogs. Insulin infused at 1 mU/kg/min together with glucose at 14 mg/kg/min for 7 days increased fasting plasma insulin concentration approximately sixfold. Plasma glucose concentration was unchanged on day 1 but was below control on day 6. Mean arterial pressure decreased from 81 ± 4 mm Hg to 70 ± 3 mm Hg, while cardiac output increased to 30 ± 8% above control by day 7. Total peripheral resistance decreased to 69 ± 5% of control. Urinary sodium excretion was significantly decreased and was accom panied by a 22% increase in extracellular fluid volume with no change in blood volume. All parameters returned to control levels during the recovery period. These data suggest that, in addition to promoting renal sodium retention, insulin may lower blood pressure and increase cardiac output through a peripheral vasodilatory effect. © 1991 by the American Journal of Hypertension, Inc.

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JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 2

ER -

The hemodynamic response to chronic hyperinsulinemia in conscious dogs

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