The health status of a village population, 7 years after a major Q fever outbreak

G. MORROY; W. VAN DER HOEK; Z. D. NANVER; P. M. SCHNEEBERGER; C. P. BLEEKER-ROVERS; J. VAN DER VELDEN; R. A. COUTINHO

doi:10.1017/S0950268815002472

The health status of a village population, 7 years after a major Q fever outbreak

G. MORROY^*, W. VAN DER HOEK, Z. D. NANVER, P. M. SCHNEEBERGER, C. P. BLEEKER-ROVERS, J. VAN DER VELDEN, R. A. COUTINHO

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

From 2007 to 2010, The Netherlands experienced a major Q fever outbreak with more than 4000 notifications. Previous studies suggested that Q fever patients could suffer long-term post-infection health impairments, especially fatigue. Our objective was to assess the Coxiella burnetii antibody prevalence and health status including fatigue, and assess their interrelationship in Herpen, a high-incidence village, 7 years after the outbreak began. In 2014, we invited all 2161 adult inhabitants for a questionnaire and a C. burnetii indirect fluorescence antibody assay (IFA). The health status was measured with the Nijmegen Clinical Screening Instrument (NCSI), consisting of eight subdomains including fatigue. Of the 70·1% (1517/2161) participants, 33·8% (513/1517) were IFA positive. Of 147 participants who were IFA positive in 2007, 25 (17%) seroreverted and were now IFA negative. Not positive IFA status, but age

Original language	English
Pages (from-to)	1153 - 1162
Journal	Epidemiology and Infection
Volume	144
Issue number	6
DOIs	https://doi.org/10.1017/S0950268815002472
Publication status	Published - Apr 2016

Keywords

Coxiella burnetii
IFA
NCSI
post-infection fatigue
Q fever

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title = "The health status of a village population, 7 years after a major Q fever outbreak",

abstract = "From 2007 to 2010, The Netherlands experienced a major Q fever outbreak with more than 4000 notifications. Previous studies suggested that Q fever patients could suffer long-term post-infection health impairments, especially fatigue. Our objective was to assess the Coxiella burnetii antibody prevalence and health status including fatigue, and assess their interrelationship in Herpen, a high-incidence village, 7 years after the outbreak began. In 2014, we invited all 2161 adult inhabitants for a questionnaire and a C. burnetii indirect fluorescence antibody assay (IFA). The health status was measured with the Nijmegen Clinical Screening Instrument (NCSI), consisting of eight subdomains including fatigue. Of the 70·1% (1517/2161) participants, 33·8% (513/1517) were IFA positive. Of 147 participants who were IFA positive in 2007, 25 (17%) seroreverted and were now IFA negative. Not positive IFA status, but age ",

keywords = "Coxiella burnetii, IFA, NCSI, post-infection fatigue, Q fever",

author = "G. MORROY and {VAN DER HOEK}, W. and NANVER, {Z. D.} and SCHNEEBERGER, {P. M.} and BLEEKER-ROVERS, {C. P.} and {VAN DER VELDEN}, J. and COUTINHO, {R. A.}",

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AU - VAN DER HOEK, W.

AU - NANVER, Z. D.

AU - SCHNEEBERGER, P. M.

AU - BLEEKER-ROVERS, C. P.

AU - VAN DER VELDEN, J.

AU - COUTINHO, R. A.

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AB - From 2007 to 2010, The Netherlands experienced a major Q fever outbreak with more than 4000 notifications. Previous studies suggested that Q fever patients could suffer long-term post-infection health impairments, especially fatigue. Our objective was to assess the Coxiella burnetii antibody prevalence and health status including fatigue, and assess their interrelationship in Herpen, a high-incidence village, 7 years after the outbreak began. In 2014, we invited all 2161 adult inhabitants for a questionnaire and a C. burnetii indirect fluorescence antibody assay (IFA). The health status was measured with the Nijmegen Clinical Screening Instrument (NCSI), consisting of eight subdomains including fatigue. Of the 70·1% (1517/2161) participants, 33·8% (513/1517) were IFA positive. Of 147 participants who were IFA positive in 2007, 25 (17%) seroreverted and were now IFA negative. Not positive IFA status, but age

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The health status of a village population, 7 years after a major Q fever outbreak

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Keywords

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