The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development

Inês Cunha-Ferreira, Anaël Chazeau, Robin R. Buijs, Riccardo Stucchi, Lena Will, Xingxiu Pan, Youri Adolfs, Christiaan van der Meer, Joanna C. Wolthuis, Olga I. Kahn, Philipp Schätzle, Maarten Altelaar, R. Jeroen Pasterkamp, Lukas C. Kapitein*, Casper C. Hoogenraad

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Cunha-Ferreira et al. report that the HAUS/augmin complex regulates neuronal migration, polarization, and development. In neurons, the HAUS complex is distributed as discrete clusters regulating local microtubule nucleation. These findings shed light into how microtubules are generated in developing neurons after centrosome inactivation in early development.

Original languageEnglish
Pages (from-to)791-800
Number of pages10
JournalCell Reports
Volume24
Issue number4
DOIs
Publication statusPublished - 24 Jul 2018

Keywords

  • actin
  • centrosome
  • development
  • microtubule
  • migration
  • neuron
  • nucleation

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