The hallmarks of CMV-specific CD8 T-cell differentiation

Sara P.H. van den Berg; Iris N. Pardieck; Josien Lanfermeijer; Delphine Sauce; Paul Klenerman; Debbie van Baarle; Ramon Arens

doi:10.1007/s00430-019-00608-7

The hallmarks of CMV-specific CD8 T-cell differentiation

Sara P.H. van den Berg, Iris N. Pardieck, Josien Lanfermeijer, Delphine Sauce, Paul Klenerman, Debbie van Baarle, Ramon Arens^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this “special” differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.

Original language	English
Pages (from-to)	365-373
Number of pages	9
Journal	Medical Microbiology and Immunology
Volume	208
Issue number	3-4
DOIs	https://doi.org/10.1007/s00430-019-00608-7
Publication status	Published - 1 Aug 2019

Keywords

CD8 T cell
Cytomegalovirus
Differentiation
Phenotype

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title = "The hallmarks of CMV-specific CD8 T-cell differentiation",

abstract = "Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this “special” differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.",

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AU - van den Berg, Sara P.H.

AU - Pardieck, Iris N.

AU - Lanfermeijer, Josien

AU - Sauce, Delphine

AU - Klenerman, Paul

AU - van Baarle, Debbie

AU - Arens, Ramon

PY - 2019/8/1

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N2 - Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this “special” differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.

AB - Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this “special” differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. In addition, we focus on whether the differentiation state of CMV-specific CD8 T cells is unique in comparison with other chronic viruses and we will discuss the possible impact of factors such as antigen exposure and aging on the advanced differentiation status of CMV-specific CD8 T cells.

KW - CD8 T cell

KW - Cytomegalovirus

KW - Differentiation

KW - Phenotype

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The hallmarks of CMV-specific CD8 T-cell differentiation

Abstract

Keywords

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