@article{73e03b42855e42aebe24119317654d55,
title = "The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project",
abstract = "BACKGROUND: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clarify the role of genetic variation in brain abnormalities underlying schizophrenia. This article describes the GENUS Consortium sample collection.METHODS: We identified existing samples collected for schizophrenia studies consisting of patients, controls, and/or individuals at familial high-risk (FHR) for schizophrenia. Samples had single nucleotide polymorphism (SNP) array data or genomic DNA, clinical and demographic data, and neuropsychological and/or brain magnetic resonance imaging (MRI) data. Data were subjected to quality control procedures at a central site.RESULTS: Sixteen research groups contributed data from 5199 psychosis patients, 4877 controls, and 725 FHR individuals. All participants have relevant demographic data and all patients have relevant clinical data. The sex ratio is 56.5% male and 43.5% female. Significant differences exist between diagnostic groups for premorbid and current IQ (both p<1×10 -10). Data from a diversity of neuropsychological tests are available for 92% of participants, and 30% have structural MRI scans (half also have diffusion-weighted MRI scans). SNP data are available for 76% of participants. The ancestry composition is 70% European, 20% East Asian, 7% African, and 3% other. CONCLUSIONS: The Consortium is investigating the genetic contribution to brain phenotypes in a schizophrenia sample collection of >10,000 participants. The breadth of data across clinical, genetic, neuropsychological, and MRI modalities provides an important opportunity for elucidating the genetic basis of neural processes underlying schizophrenia.",
keywords = "Cognition, Genetics, MRI, Neuroimaging, Neuropsychology, Schizophrenia, Endophenotypes, Humans, Middle Aged, Genetic Predisposition to Disease/genetics, Male, Cognition Disorders/diagnostic imaging, Young Adult, Polymorphism, Single Nucleotide/genetics, Statistics, Nonparametric, Aged, 80 and over, Adult, Female, Child, Genotype, Neuropsychological Tests, Schizophrenia/complications, Magnetic Resonance Imaging, Image Processing, Computer-Assisted, Adolescent, Aged",
author = "Blokland, {Gabri{\"e}lla A.M.} and {del Re}, {Elisabetta C.} and Mesholam-Gately, {Raquelle I.} and Jorge Jovicich and Trampush, {Joey W.} and Keshavan, {Matcheri S.} and DeLisi, {Lynn E} and Walters, {James T.R.} and Turner, {Jessica A.} and Malhotra, {Anil K} and Todd Lencz and Shenton, {Martha E.} and Voineskos, {Aristotle N.} and Dan Rujescu and Ina Giegling and Kahn, {Ren{\'e} S.} and Roffman, {Joshua L.} and Holt, {Daphne J.} and Stefan Ehrlich and Zora Kikinis and Paola Dazzan and Murray, {Robin M.} and {Di Forti}, Marta and Jimmy Lee and Kang Sim and Max Lam and Wolthusen, {Rick P.F.} and {de Zwarte}, {Sonja M.C.} and Esther Walton and Donna Cosgrove and Sinead Kelly and Nasim Maleki and Lisa Osiecki and Picchioni, {Marco M} and Elvira Bramon and Manuela Russo and David, {Anthony S.} and Valeria Mondelli and Reinders, {Antje A.T.S.} and Falcone, {M. Aurora} and Hartmann, {Annette M} and Bettina Konte and Morris, {Derek W.} and Michael Gill and Corvin, {Aiden P.} and Wiepke Cahn and Ho, {New Fei} and Liu, {Jian Jun} and Keefe, {Richard S.E.} and Gollub, {Randy L.} and Manoach, {Dara S.} and Calhoun, {Vince D.} and Schulz, {S. Charles} and Sponheim, {Scott R.} and Goff, {Donald C.} and Buka, {Stephen L.} and Sara Cherkerzian and Thermenos, {Heidi W.} and Marek Kubicki and Nestor, {Paul G.} and Dickie, {Erin W.} and Evangelos Vassos and Simone Ciufolini and {Reis Marques}, Tiago and Crossley, {Nicolas A.} and Purcell, {Shaun M} and Smoller, {Jordan W.} and {van Haren}, {Neeltje E.M.} and Timothea Toulopoulou and Gary Donohoe and Goldstein, {Jill M.} and Seidman, {Larry J.} and McCarley, {Robert W.} and Petryshen, {Tracey L.}",
note = "Funding Information: We are grateful for the support of all study staff and participants. Acknowledgements for each sample are provided in the Supplementary Materials. Data processing and analyses (of the legacy data) at the central site was supported by the National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) grant number R01MH092380 to T.L.P. supporting the Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium, and NIMH grant R21MH109819 to E.D.R. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",
year = "2018",
month = may,
doi = "10.1016/j.schres.2017.09.024",
language = "English",
volume = "195",
pages = "306--317",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
}