The future of autologous stem cell transplantation in systemic sclerosis

Charlotte Schimmel; Julia Spierings

doi:10.1038/s41584-025-01341-7

The future of autologous stem cell transplantation in systemic sclerosis

Charlotte Schimmel
, Julia Spierings^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Autologous haematopoietic stem cell transplantation revolutionized the treatment of severe systemic sclerosis as the first therapy able to induce long-term remission in this relentlessly fibrosing disease. Nevertheless, questions remain about patient selection, conditioning, and how this treatment fits into the evolving immune-modifying therapeutic landscape. The field should move beyond standardization towards precision therapy.

Original language	English
Pages (from-to)	145-146
Number of pages	2
Journal	Nature Reviews. Rheumatology
Volume	22
Issue number	3
Early online date	9 Dec 2025
DOIs	https://doi.org/10.1038/s41584-025-01341-7
Publication status	Published - Mar 2026

Access to Document

10.1038/s41584-025-01341-7

Cite this

@article{31eb382250ec4c39b6b9c7d33e1304b5,

title = "The future of autologous stem cell transplantation in systemic sclerosis",

abstract = "Autologous haematopoietic stem cell transplantation revolutionized the treatment of severe systemic sclerosis as the first therapy able to induce long-term remission in this relentlessly fibrosing disease. Nevertheless, questions remain about patient selection, conditioning, and how this treatment fits into the evolving immune-modifying therapeutic landscape. The field should move beyond standardization towards precision therapy.",

author = "Charlotte Schimmel and Julia Spierings",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2026",

month = mar,

doi = "10.1038/s41584-025-01341-7",

language = "English",

volume = "22",

pages = "145--146",

journal = "Nature Reviews. Rheumatology",

issn = "1759-4790",

publisher = "Nature Research",

number = "3",

}

TY - JOUR

T1 - The future of autologous stem cell transplantation in systemic sclerosis

AU - Schimmel, Charlotte

AU - Spierings, Julia

N1 - Publisher Copyright: © Springer Nature Limited 2025.

PY - 2026/3

Y1 - 2026/3

N2 - Autologous haematopoietic stem cell transplantation revolutionized the treatment of severe systemic sclerosis as the first therapy able to induce long-term remission in this relentlessly fibrosing disease. Nevertheless, questions remain about patient selection, conditioning, and how this treatment fits into the evolving immune-modifying therapeutic landscape. The field should move beyond standardization towards precision therapy.

AB - Autologous haematopoietic stem cell transplantation revolutionized the treatment of severe systemic sclerosis as the first therapy able to induce long-term remission in this relentlessly fibrosing disease. Nevertheless, questions remain about patient selection, conditioning, and how this treatment fits into the evolving immune-modifying therapeutic landscape. The field should move beyond standardization towards precision therapy.

UR - https://www.scopus.com/pages/publications/105024537629

U2 - 10.1038/s41584-025-01341-7

DO - 10.1038/s41584-025-01341-7

M3 - Comment/Letter to the editor

C2 - 41366046

SN - 1759-4790

VL - 22

SP - 145

EP - 146

JO - Nature Reviews. Rheumatology

JF - Nature Reviews. Rheumatology

IS - 3

ER -

The future of autologous stem cell transplantation in systemic sclerosis

Abstract

Access to Document

Other files and links

Embargoed Document

Fingerprint

Cite this