The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Jasper C A Broen; Marieke J H Coenen; Blanca Rueda; Torsten Witte; Leonid Padyukov; Lars Klareskog; Roger Hesselstrand; Dirk M Wuttge; Carmen Simeon; Norberto Ortego-Centeno; Miguel A González-Gay; Anna Pros; Nicholas Hunzelman; Gabriela Riemekasten; Alexander Kreuter; Madelon Vonk; Rafaella Scorza; Lorenzo Beretta; Paulo Airò; Piet L C M van Riel; Robert Kimberly; Javier Martin; Jeffrey Edberg; Timothy R D J Radstake

doi:10.3899/jrheum.100427

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Jasper C A Broen, Marieke J H Coenen, Blanca Rueda, Torsten Witte, Leonid Padyukov, Lars Klareskog, Roger Hesselstrand, Dirk M Wuttge, Carmen Simeon, Norberto Ortego-Centeno, Miguel A González-Gay, Anna Pros, Nicholas Hunzelman, Gabriela Riemekasten, Alexander Kreuter, Madelon Vonk, Rafaella Scorza, Lorenzo Beretta, Paulo Airò, Piet L C M van RielRobert Kimberly, Javier Martin, Jeffrey Edberg, Timothy R D J Radstake

Rheumatology & Clinical Immunology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.

METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.

RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.

CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

Original language	English
Pages (from-to)	446-9
Number of pages	4
Journal	Journal of Rheumatology
Volume	38
Issue number	3
DOIs	https://doi.org/10.3899/jrheum.100427
Publication status	Published - 2011

Keywords

Aged
Antigens, CD
Arthritis, Rheumatoid
Europe
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Fc
Scleroderma, Systemic
Journal Article
Research Support, Non-U.S. Gov't

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Broen, J. C. A., Coenen, M. J. H., Rueda, B., Witte, T., Padyukov, L., Klareskog, L., Hesselstrand, R., Wuttge, D. M., Simeon, C., Ortego-Centeno, N., González-Gay, M. A., Pros, A., Hunzelman, N., Riemekasten, G., Kreuter, A., Vonk, M., Scorza, R., Beretta, L., Airò, P., ... Radstake, T. R. D. J. (2011). The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility. Journal of Rheumatology, 38(3), 446-9. https://doi.org/10.3899/jrheum.100427

@article{a2add005bc734f6c8f7630a9d093b3bb,

title = "The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility",

abstract = "OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.",

keywords = "Aged, Antigens, CD, Arthritis, Rheumatoid, Europe, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Fc, Scleroderma, Systemic, Journal Article, Research Support, Non-U.S. Gov't",

author = "Broen, {Jasper C A} and Coenen, {Marieke J H} and Blanca Rueda and Torsten Witte and Leonid Padyukov and Lars Klareskog and Roger Hesselstrand and Wuttge, {Dirk M} and Carmen Simeon and Norberto Ortego-Centeno and Gonz{\'a}lez-Gay, {Miguel A} and Anna Pros and Nicholas Hunzelman and Gabriela Riemekasten and Alexander Kreuter and Madelon Vonk and Rafaella Scorza and Lorenzo Beretta and Paulo Air{\`o} and {van Riel}, {Piet L C M} and Robert Kimberly and Javier Martin and Jeffrey Edberg and Radstake, {Timothy R D J}",

year = "2011",

doi = "10.3899/jrheum.100427",

language = "English",

volume = "38",

pages = "446--9",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "3",

}

Broen, JCA, Coenen, MJH, Rueda, B, Witte, T, Padyukov, L, Klareskog, L, Hesselstrand, R, Wuttge, DM, Simeon, C, Ortego-Centeno, N, González-Gay, MA, Pros, A, Hunzelman, N, Riemekasten, G, Kreuter, A, Vonk, M, Scorza, R, Beretta, L, Airò, P, van Riel, PLCM, Kimberly, R, Martin, J, Edberg, J & Radstake, TRDJ 2011, 'The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility', Journal of Rheumatology, vol. 38, no. 3, pp. 446-9. https://doi.org/10.3899/jrheum.100427

TY - JOUR

T1 - The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

AU - Broen, Jasper C A

AU - Coenen, Marieke J H

AU - Rueda, Blanca

AU - Witte, Torsten

AU - Padyukov, Leonid

AU - Klareskog, Lars

AU - Hesselstrand, Roger

AU - Wuttge, Dirk M

AU - Simeon, Carmen

AU - Ortego-Centeno, Norberto

AU - González-Gay, Miguel A

AU - Pros, Anna

AU - Hunzelman, Nicholas

AU - Riemekasten, Gabriela

AU - Kreuter, Alexander

AU - Vonk, Madelon

AU - Scorza, Rafaella

AU - Beretta, Lorenzo

AU - Airò, Paulo

AU - van Riel, Piet L C M

AU - Kimberly, Robert

AU - Martin, Javier

AU - Edberg, Jeffrey

AU - Radstake, Timothy R D J

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

AB - OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

KW - Aged

KW - Antigens, CD

KW - Arthritis, Rheumatoid

KW - Europe

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Meta-Analysis as Topic

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Fc

KW - Scleroderma, Systemic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3899/jrheum.100427

DO - 10.3899/jrheum.100427

M3 - Article

C2 - 21159834

SN - 0315-162X

VL - 38

SP - 446

EP - 449

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 3

ER -

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility

Abstract

Keywords

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