The full spectrum of human naive T cells

Theo van Den Broek, José A.M. Borghans, Femke van Wijk*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.

Original languageEnglish
Pages (from-to)363-373
Number of pages11
JournalNature Reviews Immunology
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 2018

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