The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Jelle J.F. Sleeboom; Gilles S. van Tienderen; Katja Schenke-Layland; Luc J.W. van der Laan; Antoine A. Khalil; Monique M.A. Verstegen

doi:10.1126/scitranslmed.adg3840

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Jelle J.F. Sleeboom, Gilles S. van Tienderen, Katja Schenke-Layland, Luc J.W. van der Laan, Antoine A. Khalil^*, Monique M.A. Verstegen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM’s role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

Original language	English
Article number	3840
Journal	Science translational medicine
Volume	16
Issue number	728
DOIs	https://doi.org/10.1126/scitranslmed.adg3840
Publication status	Published - 3 Jan 2024

Keywords

Humans
Biomechanical Phenomena
Neoplasms/pathology
Extracellular Matrix
Integrins
Tumor Microenvironment

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10.1126/scitranslmed.adg3840

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title = "The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets",

abstract = "The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor{\textquoteright}s cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM{\textquoteright}s role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.",

keywords = "Humans, Biomechanical Phenomena, Neoplasms/pathology, Extracellular Matrix, Integrins, Tumor Microenvironment",

author = "Sleeboom, {Jelle J.F.} and {van Tienderen}, {Gilles S.} and Katja Schenke-Layland and {van der Laan}, {Luc J.W.} and Khalil, {Antoine A.} and Verstegen, {Monique M.A.}",

note = "Publisher Copyright: {\textcopyright} 2024 The authors, some rights reserved; exclusive licensee american association for the advancement of Science. no claim to original U.S. Government works.",

year = "2024",

month = jan,

day = "3",

doi = "10.1126/scitranslmed.adg3840",

language = "English",

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journal = "Science translational medicine",

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T2 - From biomechanics to therapeutic targets

AU - Sleeboom, Jelle J.F.

AU - van Tienderen, Gilles S.

AU - Schenke-Layland, Katja

AU - van der Laan, Luc J.W.

AU - Khalil, Antoine A.

AU - Verstegen, Monique M.A.

PY - 2024/1/3

Y1 - 2024/1/3

N2 - The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM’s role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

AB - The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor’s cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM’s role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

KW - Humans

KW - Biomechanical Phenomena

KW - Neoplasms/pathology

KW - Extracellular Matrix

KW - Integrins

KW - Tumor Microenvironment

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U2 - 10.1126/scitranslmed.adg3840

DO - 10.1126/scitranslmed.adg3840

M3 - Review article

C2 - 38170791

SN - 1946-6234

VL - 16

JO - Science translational medicine

JF - Science translational medicine

IS - 728

M1 - 3840

ER -

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Abstract

Keywords

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