TY - JOUR
T1 - The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
T2 - Incidence and First-Episode Case-Control Programme
AU - Gayer-Anderson, Charlotte
AU - Jongsma, Hannah E.
AU - Di Forti, Marta
AU - Quattrone, Diego
AU - Velthorst, Eva
AU - de Haan, Lieuwe
AU - Selten, Jean-Paul
AU - Szoke, Andrei
AU - Llorca, Pierre-Michel
AU - Tortelli, Andrea
AU - Arango, Celso
AU - Bobes, Julio
AU - Bernardo, Miguel
AU - Sanjuan, Julio
AU - Santos, Jose Luis
AU - Arrojo, Manuel
AU - Parellada, Mara
AU - Tarricone, Ilaria
AU - Berardi, Domenico
AU - Ruggeri, Mirella
AU - Lasalvia, Antonio
AU - Ferraro, Laura
AU - La Cascia, Caterina
AU - La Barbera, Daniele
AU - Menezes, Paulo Rossi
AU - Del-Ben, Cristina Marta
AU - Rutten, Bart P.
AU - van Os, Jim
AU - Jones, Peter B.
AU - Murray, Robin M.
AU - Kirkbride, James B.
AU - Morgan, Craig
N1 - Funding Information:
The EU-GEI Study is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community?s Seventh Framework Programme, and Grant 2012/0417-0 from the S?o Paulo Research Foundation.
Funding Information:
The EU-GEI Study is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme, and Grant 2012/0417-0 from the São Paulo Research Foundation.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/5/1
Y1 - 2020/5/1
N2 - PURPOSE: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.METHODS: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.CONCLUSIONS: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
AB - PURPOSE: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders.METHODS: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort.CONCLUSIONS: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
KW - Case–control
KW - EU-GEI
KW - Environment–environment interactions
KW - First-episode psychosis
KW - Gene–environment interactions
KW - Incidence
KW - Environment-environment interactions
KW - Gene-environment interactions
KW - Case-control
UR - http://www.scopus.com/inward/record.url?scp=85078807489&partnerID=8YFLogxK
U2 - 10.1007/s00127-020-01831-x
DO - 10.1007/s00127-020-01831-x
M3 - Article
C2 - 31974809
SN - 0933-7954
VL - 55
SP - 645
EP - 657
JO - Social Psychiatry and Psychiatric Epidemiology
JF - Social Psychiatry and Psychiatric Epidemiology
IS - 5
ER -