The emerging role of retromer in neuroprotection

Kirsty J. McMillan; Hendrik C. Korswagen; Peter J. Cullen

doi:10.1016/j.ceb.2017.02.004

The emerging role of retromer in neuroprotection

Kirsty J. McMillan, Hendrik C. Korswagen, Peter J. Cullen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell–cell and cell–matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

Original language	English
Pages (from-to)	72-82
Number of pages	11
Journal	Current Opinion in Cell Biology
Volume	47
DOIs	https://doi.org/10.1016/j.ceb.2017.02.004
Publication status	Published - Aug 2017

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title = "The emerging role of retromer in neuroprotection",

abstract = "Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell–cell and cell–matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.",

author = "McMillan, {Kirsty J.} and Korswagen, {Hendrik C.} and Cullen, {Peter J.}",

note = "Funding Information: This work was supported by the MRC (MR/K018299/1) and the Wellcome Trust (089928 and 104568) to P.J.C. Publisher Copyright: {\textcopyright} 2017 The Authors",

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AB - Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell–cell and cell–matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

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The emerging role of retromer in neuroprotection

Abstract

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