The El Escorial criteria: Strengths and weaknesses

F. Agosta; A. Al-Chalabi; Massimo Filippi; O. Hardiman; R. Kaji; V. Meininger; I. Nakano; P. Shaw; J.M. Shefner; L.H. Van Den Berg; A. Ludolph

doi:10.3109/21678421.2014.964258

The El Escorial criteria: Strengths and weaknesses

F. Agosta, A. Al-Chalabi, Massimo Filippi, O. Hardiman, R. Kaji, V. Meininger, I. Nakano, P. Shaw, J.M. Shefner, L.H. Van Den Berg, A. Ludolph

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. © 2014 Informa Healthcare.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Volume	16
Issue number	1-2
DOIs	https://doi.org/10.3109/21678421.2014.964258
Publication status	Published - 2015

Keywords

amyotrophic lateral sclerosis
Article
clinical practice
clinical trial (topic)
diffusion tensor imaging
disease association
disease classification
early diagnosis
El Escorial criteria
electrophysiology
familial disease
frontotemporal dementia
human
nuclear magnetic resonance imaging
priority journal
neuroimaging
neurologic examination
pathophysiology
procedures
severity of illness index
standards, Amyotrophic Lateral Sclerosis
Clinical Trials as Topic
Frontotemporal Dementia
Humans
Neuroimaging
Neurologic Examination
Severity of Illness Index

Access to Document

10.3109/21678421.2014.964258

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925609979&doi=10.3109%2f21678421.2014.964258&partnerID=40&md5=bd88759ae12727fe629eea11f4ff2bc0

Cite this

@article{ed0cb7722f404741afe1b37ceefb97d9,

title = "The El Escorial criteria: Strengths and weaknesses",

abstract = "The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. {\textcopyright} 2014 Informa Healthcare.",

keywords = "amyotrophic lateral sclerosis, Article, clinical practice, clinical trial (topic), diffusion tensor imaging, disease association, disease classification, early diagnosis, El Escorial criteria, electrophysiology, familial disease, frontotemporal dementia, human, nuclear magnetic resonance imaging, priority journal, neuroimaging, neurologic examination, pathophysiology, procedures, severity of illness index, standards, Amyotrophic Lateral Sclerosis, Clinical Trials as Topic, Frontotemporal Dementia, Humans, Neuroimaging, Neurologic Examination, Severity of Illness Index",

author = "F. Agosta and A. Al-Chalabi and Massimo Filippi and O. Hardiman and R. Kaji and V. Meininger and I. Nakano and P. Shaw and J.M. Shefner and \{Van Den Berg\}, L.H. and A. Ludolph",

note = "cited By 8",

year = "2015",

doi = "10.3109/21678421.2014.964258",

language = "English",

volume = "16",

pages = "1--7",

journal = "Amyotrophic Lateral Sclerosis \& Frontotemporal Degeneration",

issn = "2167-8421",

publisher = "Taylor and Francis Ltd.",

number = "1-2",

}

TY - JOUR

T1 - The El Escorial criteria

T2 - Strengths and weaknesses

AU - Agosta, F.

AU - Al-Chalabi, A.

AU - Filippi, Massimo

AU - Hardiman, O.

AU - Kaji, R.

AU - Meininger, V.

AU - Nakano, I.

AU - Shaw, P.

AU - Shefner, J.M.

AU - Van Den Berg, L.H.

AU - Ludolph, A.

N1 - cited By 8

PY - 2015

Y1 - 2015

N2 - The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. © 2014 Informa Healthcare.

AB - The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. © 2014 Informa Healthcare.

KW - amyotrophic lateral sclerosis

KW - Article

KW - clinical practice

KW - clinical trial (topic)

KW - diffusion tensor imaging

KW - disease association

KW - disease classification

KW - early diagnosis

KW - El Escorial criteria

KW - electrophysiology

KW - familial disease

KW - frontotemporal dementia

KW - human

KW - nuclear magnetic resonance imaging

KW - priority journal

KW - neuroimaging

KW - neurologic examination

KW - pathophysiology

KW - procedures

KW - severity of illness index

KW - standards, Amyotrophic Lateral Sclerosis

KW - Clinical Trials as Topic

KW - Frontotemporal Dementia

KW - Humans

KW - Neuroimaging

KW - Neurologic Examination

KW - Severity of Illness Index

U2 - 10.3109/21678421.2014.964258

DO - 10.3109/21678421.2014.964258

M3 - Article

SN - 2167-8421

VL - 16

SP - 1

EP - 7

JO - Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration

IS - 1-2

ER -

The El Escorial criteria: Strengths and weaknesses

Abstract

Keywords

Access to Document

Fingerprint

Cite this