TY - JOUR
T1 - The efficacy of antipsychotics in the treatment of physical aggressive behavior in patients with dementia in nursing homes
AU - Nawzad, Sina
AU - Cahn, Wiepke
AU - Abdullah-Koolmees, Heshu
N1 - Publisher Copyright:
© The Author(s), 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Patients with dementia often suffer from behavioral changes. A common behavioral change is acute physical aggressive behavior which is the most distressing change. This can lead to harm, which is especially problematic in nursing homes. Despite the serious safety concerns, antipsychotics are often prescribed to combat this problem. This article is aimed to review the evidence of the efficacy of utilizing antipsychotics in acutely treating physical aggressive behavior in patients with dementia in nursing homes. Therefore, a systematic literature search was performed. The results demonstrated that a meta-analysis confirmed statistically significant reduction in physical aggression when risperidone was compared to placebo. However, a randomized controlled trial showed no change in physical aggressive behavior between quetiapine and placebo. More research is needed to fully investigate the benefits of physical aggressive behavior and safety concerns of all the antipsychotics in patients with dementia in nursing homes.
AB - Patients with dementia often suffer from behavioral changes. A common behavioral change is acute physical aggressive behavior which is the most distressing change. This can lead to harm, which is especially problematic in nursing homes. Despite the serious safety concerns, antipsychotics are often prescribed to combat this problem. This article is aimed to review the evidence of the efficacy of utilizing antipsychotics in acutely treating physical aggressive behavior in patients with dementia in nursing homes. Therefore, a systematic literature search was performed. The results demonstrated that a meta-analysis confirmed statistically significant reduction in physical aggression when risperidone was compared to placebo. However, a randomized controlled trial showed no change in physical aggressive behavior between quetiapine and placebo. More research is needed to fully investigate the benefits of physical aggressive behavior and safety concerns of all the antipsychotics in patients with dementia in nursing homes.
KW - Cohen-Mansfield Agitation Inventory (CMAI) scale
KW - aggressive behavior
KW - antipsychotics
KW - dementia
KW - neuropsychiatric symptoms
UR - http://www.scopus.com/inward/record.url?scp=85174289877&partnerID=8YFLogxK
U2 - 10.1177/20451253221097452
DO - 10.1177/20451253221097452
M3 - Review article
C2 - 35600754
SN - 2045-1253
VL - 12
SP - 1
EP - 5
JO - Therapeutic advances in psychopharmacology
JF - Therapeutic advances in psychopharmacology
ER -