TY - JOUR
T1 - The effect of sesame, canola, and sesame-canola oils on cardiometabolic risk factors in overweight adults
T2 - a three-way randomized triple-blind crossover clinical trial
AU - Moghtaderi, Fatemeh
AU - Amiri, Mojgan
AU - Raeisi-Dehkordi, Hamidreza
AU - Zimorovat, Alireza
AU - Mohyadini, Matin
AU - Salehi-Abargouei, Amin
N1 - Funding Information:
The study was jointly funded by Shahid Sadoughi University of Medical sciences and Datis Corporation. The investigators declared that they did not have a direct financial relationship with Datis Corporation and Shahid Sadoughi University of Medical Sciences received the funds and delivered them to the investigators. Datis Corporation did not take any part in the conception, design, the execution of the study protocol, and the reporting of the study results. The corporation did not have any other relationship with the investigators. The authors declare that they have no other potential personal or financial conflicts of interest. The principal investigator (ASA) declares that he has full access to the data and samples provided by this project.
Funding Information:
We thank all the participants for their voluntary and enthusiastic involvement in the study. Also, we are thankful from Shahid Sadoughi University of Medical Sciences (http://www.ssu.ac.ir) and Neshatavar food industry company (Datis Corporation; http://www.neshatavar.com/?l=EN) for their joint funding of this study. Datis Corporation also provided all of the treatment oils consumed during the study including canola, sesame, sesame-canola and sunflower oils. Datis Corporation had no role in the design and conduct of this manuscript; collection, management, analysis, and interpretation of the data; and preparation of this manuscript. We thank the research council of Nutrition and Food Security Research Center and diabetes research center of Shahid Sadoughi University of Medical Sciences, Yazd, Iran, for their scientific support and close cooperation, respectively.
Publisher Copyright:
© 2022 John Wiley & Sons Ltd.
PY - 2022/2
Y1 - 2022/2
N2 - Limited data exist on the cardiometabolic effects of sesame oil compared with canola oil. In the present study, 77 overweight adults were randomized to replace their regularly consumed oils with canola (CO), sesame (SO), and sesame-canola oils (SCO, 40% SO, and 60% CO) in three 9-week phases. Blood pressure, visceral adiposity index, serum apo-proteins (APOs) and lipid profile, glycemic control markers, kidney markers, liver enzymes, and cardiovascular disease risk scores were assessed at baseline and endline. After adjustment for confounders, SO significantly reduced serum alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all participants, increased serum urea compared to SCO in males, and decreased serum alkaline phosphatase compared to other oils in males, and improved serum high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) compared to SCO, and eGFR compared with CO in females (p ≤ 0.05). Canola oil significantly improved serum Apo A1 and APO B/A ratio compared with SO, in males (p ≤ 0.05). Sesame-canola oil significantly reduced serum urea compared to other oils in all participants (p ≤ 0.05). Sesame oil and SCO might beneficially affect serum ALT and urea, respectively. Intervention oils might have different cardiometabolic effects in each gender. Further studies are needed to confirm our results (Trial registration code: IRCT2016091312571N6).
AB - Limited data exist on the cardiometabolic effects of sesame oil compared with canola oil. In the present study, 77 overweight adults were randomized to replace their regularly consumed oils with canola (CO), sesame (SO), and sesame-canola oils (SCO, 40% SO, and 60% CO) in three 9-week phases. Blood pressure, visceral adiposity index, serum apo-proteins (APOs) and lipid profile, glycemic control markers, kidney markers, liver enzymes, and cardiovascular disease risk scores were assessed at baseline and endline. After adjustment for confounders, SO significantly reduced serum alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all participants, increased serum urea compared to SCO in males, and decreased serum alkaline phosphatase compared to other oils in males, and improved serum high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) compared to SCO, and eGFR compared with CO in females (p ≤ 0.05). Canola oil significantly improved serum Apo A1 and APO B/A ratio compared with SO, in males (p ≤ 0.05). Sesame-canola oil significantly reduced serum urea compared to other oils in all participants (p ≤ 0.05). Sesame oil and SCO might beneficially affect serum ALT and urea, respectively. Intervention oils might have different cardiometabolic effects in each gender. Further studies are needed to confirm our results (Trial registration code: IRCT2016091312571N6).
KW - canola oil
KW - cardiometabolic risk factors
KW - sesame oil
UR - http://www.scopus.com/inward/record.url?scp=85123503982&partnerID=8YFLogxK
U2 - 10.1002/ptr.7381
DO - 10.1002/ptr.7381
M3 - Article
C2 - 35066950
AN - SCOPUS:85123503982
SN - 0951-418X
VL - 36
SP - 1043
EP - 1057
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 2
ER -