Abstract
Introduction: Mercaptopurine, a thiopurine, is used in various disorders of immune reg-ulation, such as autoimmune hepatitis. Thiopurine metabolism is complex with risk for overdosing, especially when metabolism is impaired by liver dysfunction. Hepatotoxicity may be due to mer-captopurine overdose and is often reversible after prompt cessation of the drug. Case Presentation: Treatment of thiopurine toxicity is mainly supportive and literature on en-hanced elimination by renal replacement therapy is ambiguous. Conclusion: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.
Original language | English |
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Pages (from-to) | 299-302 |
Number of pages | 4 |
Journal | Current Drug Safety |
Volume | 19 |
Issue number | 2 |
DOIs | |
Publication status | Published - 3 Feb 2024 |
Keywords
- autoimmune hepatitis
- concentrations
- hepatotoxicity
- Mercaptopurine toxicity
- renal replacement therapy
- thiopurine toxicity