TY - JOUR
T1 - The effect of preprandial versus postprandial physical activity on glycaemia
T2 - Meta-analysis of human intervention studies
AU - Slebe, Romy
AU - Wenker, Eva
AU - Schoonmade, Linda J.
AU - Bouman, Emma J.
AU - Blondin, Denis P.
AU - Campbell, David J.T.
AU - Carpentier, André C.
AU - Hoeks, Joris
AU - Raina, Parminder
AU - Schrauwen, Patrick
AU - Serlie, Mireille J.
AU - Jan Stenvers, Dirk
AU - de Mutsert, Renée
AU - Beulens, Joline W.J.
AU - Rutters, Femke
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/4
Y1 - 2024/4
N2 - This meta-analysis aims to investigate the effect of preprandial physical activity (PA) versus postprandial PA on glycaemia in human intervention studies. Medline and Embase.com were searched until February 2023 for intervention studies in adults, directly comparing preprandial PA versus postprandial PA on glycaemia. Studies were screened using ASReview (34,837) and full texts were read by two independent reviewers (42 full text, 28 included). Results were analysed using pooled mean differences in random-effects models. Studies were either acute response studies (n = 21) or Randomized Controlled Trials (RCTs) over multiple weeks (n = 7). In acute response studies, postprandial outcomes followed the expected physiological patterns, and outcomes measured over 24 h showed no significant differences. For the RCTs, glucose area under the curve during a glucose tolerance test was slightly, but not significantly lower in preprandial PA vs postprandial PA (-0.29 [95 %CI:-0.66, 0.08] mmol/L, I2 = 64.36 %). Subgroup analyses (quality, health status, etc.) did not significantly change the outcomes. In conclusion, we found no differences between preprandial PA versus postprandial PA on glycaemia both after one PA bout as well as after multiple weeks of PA. The studies were of low to moderate quality of evidence as assessed by GRADE, showed contradictive results, included no long-term studies and used various designs and populations.
AB - This meta-analysis aims to investigate the effect of preprandial physical activity (PA) versus postprandial PA on glycaemia in human intervention studies. Medline and Embase.com were searched until February 2023 for intervention studies in adults, directly comparing preprandial PA versus postprandial PA on glycaemia. Studies were screened using ASReview (34,837) and full texts were read by two independent reviewers (42 full text, 28 included). Results were analysed using pooled mean differences in random-effects models. Studies were either acute response studies (n = 21) or Randomized Controlled Trials (RCTs) over multiple weeks (n = 7). In acute response studies, postprandial outcomes followed the expected physiological patterns, and outcomes measured over 24 h showed no significant differences. For the RCTs, glucose area under the curve during a glucose tolerance test was slightly, but not significantly lower in preprandial PA vs postprandial PA (-0.29 [95 %CI:-0.66, 0.08] mmol/L, I2 = 64.36 %). Subgroup analyses (quality, health status, etc.) did not significantly change the outcomes. In conclusion, we found no differences between preprandial PA versus postprandial PA on glycaemia both after one PA bout as well as after multiple weeks of PA. The studies were of low to moderate quality of evidence as assessed by GRADE, showed contradictive results, included no long-term studies and used various designs and populations.
KW - Blood glucose
KW - Exercise
KW - Glycaemic control
KW - Postprandial period
KW - Preprandial period
KW - Timing
UR - http://www.scopus.com/inward/record.url?scp=85189082551&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2024.111638
DO - 10.1016/j.diabres.2024.111638
M3 - Review article
C2 - 38548105
AN - SCOPUS:85189082551
SN - 0168-8227
VL - 210
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 111638
ER -