The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study

A. J.C. Slooter; M. Cruts; A. Ott; M. L. Bots; J. C.M. Witteman; A. Hofman; C. Van Broeckhoven; M. M.B. Breteler; C. M. Van Duijn

The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study

A. J.C. Slooter^*
, M. Cruts
, A. Ott
, M. L. Bots
, J. C.M. Witteman
, A. Hofman
, C. Van Broeckhoven
, M. M.B. Breteler
, C. M. Van Duijn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

Abstract

The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-ε4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.

Original language	English
Pages (from-to)	1593-1595
Number of pages	3
Journal	Neurology
Volume	53
Issue number	7
Publication status	Published - 22 Oct 1999
Externally published	Yes

Keywords

APOE
Atherosclerosis
Dementia
The Rotterdam Study

Cite this

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title = "The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study",

abstract = "The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-ε4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.",

keywords = "APOE, Atherosclerosis, Dementia, The Rotterdam Study",

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T1 - The effect of APOE on dementia is not through atherosclerosis

T2 - The Rotterdam Study

AU - Slooter, A. J.C.

AU - Cruts, M.

AU - Ott, A.

AU - Bots, M. L.

AU - Witteman, J. C.M.

AU - Hofman, A.

AU - Van Broeckhoven, C.

AU - Breteler, M. M.B.

AU - Van Duijn, C. M.

PY - 1999/10/22

Y1 - 1999/10/22

N2 - The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-ε4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.

AB - The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-ε4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.

KW - APOE

KW - Atherosclerosis

KW - Dementia

KW - The Rotterdam Study

UR - https://www.scopus.com/pages/publications/0032692882

M3 - Article

C2 - 10534277

AN - SCOPUS:0032692882

SN - 0028-3878

VL - 53

SP - 1593

EP - 1595

JO - Neurology

JF - Neurology

IS - 7

ER -

The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study

Abstract

Keywords

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