The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data

Wei Chen; Jan-Jakob Sonke; Joep Stroom; Harry Bartelink; Marcel Verheij; Kenneth Gilhuijs

doi:10.1016/j.radonc.2015.01.010

The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data

Wei Chen
, Jan-Jakob Sonke
, Joep Stroom
, Harry Bartelink
, Marcel Verheij
, Kenneth Gilhuijs^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD) in relation to treatment outcome.

Materials and methods: We employed a treatment simulation framework which contains mathematic models for describing the load and spread of MSD based on a retrospective cohort of breast pathology specimens, a surgery simulation model for estimating the remaining MSD quantity and a tumor control probability model for predicting the risk of local recurrence following radiotherapy.

Results: The average MSD cell quantities around the primary tumor in younger (age

Conclusion: The higher local recurrence rate in younger patients could be explained by larger clonogenic microscopic disease cell quantity, even though the microscopic disease cells were found to be more radiosensitive. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	314-321
Number of pages	8
Journal	Radiotherapy & Oncology
Volume	114
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2015.01.010
Publication status	Published - Mar 2015

Keywords

Age
Breast conserving therapy
Microscopic disease quantity
Monte-Carlo simulation
Radiosensitivity
Tumor control probability
TUMOR-CONTROL PROBABILITY
LOCAL RECURRENCE
CONSERVATIVE SURGERY
CANCER PATIENTS
STAGE-I
IMPACT
RADIOTHERAPY
TRIAL
PROGNOSIS
SURVIVAL

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10.1016/j.radonc.2015.01.010

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@article{1b11ed1162904b6da08812c47a770521,

title = "The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data",

abstract = "Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD) in relation to treatment outcome.Materials and methods: We employed a treatment simulation framework which contains mathematic models for describing the load and spread of MSD based on a retrospective cohort of breast pathology specimens, a surgery simulation model for estimating the remaining MSD quantity and a tumor control probability model for predicting the risk of local recurrence following radiotherapy.Results: The average MSD cell quantities around the primary tumor in younger (ageConclusion: The higher local recurrence rate in younger patients could be explained by larger clonogenic microscopic disease cell quantity, even though the microscopic disease cells were found to be more radiosensitive. (c) 2015 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Age, Breast conserving therapy, Microscopic disease quantity, Monte-Carlo simulation, Radiosensitivity, Tumor control probability, TUMOR-CONTROL PROBABILITY, LOCAL RECURRENCE, CONSERVATIVE SURGERY, CANCER PATIENTS, STAGE-I, IMPACT, RADIOTHERAPY, TRIAL, PROGNOSIS, SURVIVAL",

author = "Wei Chen and Jan-Jakob Sonke and Joep Stroom and Harry Bartelink and Marcel Verheij and Kenneth Gilhuijs",

year = "2015",

month = mar,

doi = "10.1016/j.radonc.2015.01.010",

language = "English",

volume = "114",

pages = "314--321",

journal = "Radiotherapy \& Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - The effect of age in breast conserving therapy

T2 - A retrospective analysis on pathology and clinical outcome data

AU - Chen, Wei

AU - Sonke, Jan-Jakob

AU - Stroom, Joep

AU - Bartelink, Harry

AU - Verheij, Marcel

AU - Gilhuijs, Kenneth

PY - 2015/3

Y1 - 2015/3

N2 - Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD) in relation to treatment outcome.Materials and methods: We employed a treatment simulation framework which contains mathematic models for describing the load and spread of MSD based on a retrospective cohort of breast pathology specimens, a surgery simulation model for estimating the remaining MSD quantity and a tumor control probability model for predicting the risk of local recurrence following radiotherapy.Results: The average MSD cell quantities around the primary tumor in younger (ageConclusion: The higher local recurrence rate in younger patients could be explained by larger clonogenic microscopic disease cell quantity, even though the microscopic disease cells were found to be more radiosensitive. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

AB - Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD) in relation to treatment outcome.Materials and methods: We employed a treatment simulation framework which contains mathematic models for describing the load and spread of MSD based on a retrospective cohort of breast pathology specimens, a surgery simulation model for estimating the remaining MSD quantity and a tumor control probability model for predicting the risk of local recurrence following radiotherapy.Results: The average MSD cell quantities around the primary tumor in younger (ageConclusion: The higher local recurrence rate in younger patients could be explained by larger clonogenic microscopic disease cell quantity, even though the microscopic disease cells were found to be more radiosensitive. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

KW - Age

KW - Breast conserving therapy

KW - Microscopic disease quantity

KW - Monte-Carlo simulation

KW - Radiosensitivity

KW - Tumor control probability

KW - TUMOR-CONTROL PROBABILITY

KW - LOCAL RECURRENCE

KW - CONSERVATIVE SURGERY

KW - CANCER PATIENTS

KW - STAGE-I

KW - IMPACT

KW - RADIOTHERAPY

KW - TRIAL

KW - PROGNOSIS

KW - SURVIVAL

U2 - 10.1016/j.radonc.2015.01.010

DO - 10.1016/j.radonc.2015.01.010

M3 - Article

C2 - 25640300

SN - 0167-8140

VL - 114

SP - 314

EP - 321

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 3

ER -

The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data

Abstract

Keywords

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