The diagnostic value of salivary fluid levels of β2-microglubulin, lysozyme and lactoferrin for primary Sjögren's synrome

H. M. Markusse*, H. G. Otten, Th M. Vroom, T. J.M. Smeets, N. Fokkens, F. C. Breedveld

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

In search of a simple non-invasive diagnostic test for primary Sjögren's syndrome (SS) the concentration of β2-microglobulin (β2-m), lyzozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in whom the diagnosis could be excluded (NON-SS) and in 41 normal control individuals. Salivary fluid levels of β2-m, LZM and Lf exceeding the mean+2×standard deviation of healthy control valuese were found in respectively 58%, 23%, and 26% of the primary SS patients and in 7%., 11% and 0% of the NON-SS patients. The results of this study inndicate that due to the low sensitivity the tests are not suitable as a screening procedure for patients suspected of having primary SS However, measurement of β2-m in stimulated parotid saliva may be used as an adjunctive diagnostic test for primary SS.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalClinical Rheumatology
Volume11
Issue number4
DOIs
Publication statusPublished - 1 Dec 1992

Keywords

  • β2-microglobulin
  • Lactoferrin
  • Lysozyme
  • Saliva
  • Sjögren's
  • Syndrome

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