The diagnostic performance of dual energy CT for diagnosing gout: a systematic literature review and meta-analysis

Mihaela Gamala*, Johannes W.G. Jacobs, Jaap M. Van Laar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

OBJECTIVE: This study aimed to assess the utility of dual energy CT (DECT) for diagnosing gout.

METHODS: A systematic literature search was performed in PubMed, EMBASE and Cochrane Library. Studies evaluating the utility of DECT for diagnosing gout were included. Reference standards were detection of monosodium urate crystals at SF assessment or a validated set of criteria. The methodological quality of studies was evaluated according to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 criteria. Data from person-based and joint-/localization-based evaluations were pooled separately, and subgroup analyses for disease stage/duration and reference standard were performed.

RESULTS: Ten studies were included; in person-based evaluations, the pooled (95% CI) sensitivity and specificity were 0.81 (0.77, 0.86) and 0.91 (0.85, 0.95), respectively. In joint-based evaluations, they were 0.83 (0.79, 0.86) and 0.88 (0.83, 0.92), respectively. At short disease duration (⩽6 weeks), the pooled (95% CI) sensitivity and specificity at the joint level were 0.55 (0.46, 0.64) and 0.89 (0.84, 0.94), respectively.

CONCLUSION: DECT has a high diagnostic accuracy in established gout, but its diagnostic sensitivity is low in subjects with recent onset gout.

Original languageEnglish
Pages (from-to)2117-2121
Number of pages5
JournalRheumatology (Oxford, England)
Volume58
Issue number12
Early online date14 May 2019
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • DECT
  • gout
  • review
  • utility

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