@article{d11979ad17d84a49b46c215663695455,
title = "The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy",
abstract = "BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed.METHODS: (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3-7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3-7 were related to adverse outcome in univariate and the CUS of day 3-7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II).RESULTS: Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5-4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7-4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89).CONCLUSION: This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.",
author = "Annink, {Kim V} and {de Vries}, {Linda S} and Floris Groenendaal and Vijlbrief, {Daniel C} and Weeke, {Lauren C} and Roehr, {Charles C} and Maarten Lequin and Reiss, {Irwin K M} and Paul Govaert and Benders, {Manon J N L} and Jeroen Dudink",
note = "Funding Information: Competing interests: F.G. is the founder of 2-iminobiotin and medicolegal expert in cases of perinatal asphyxia. F.G. also received grant support from Neurophyxia. L.S.d.V. received lecture fees for lectures from Genesis Research Trust for the ultrasound course in Imperial College London and at the brain monitoring meeting in Cork in 2017. C.C.R. has received lecture fees from various pharmaceutical and medical devices companies on matters unrelated to the topic in this supplement, and received grant funding from Chiesi Pharamceutical Grant for investigating specific pharmacodynamics in newborn infants, also unrelated to the manuscripts in this supplement. The other authors have no conflict of interest to declare. Funding Information: The authors thank all neonatologists, fellows and physician assistants from the University Medical Center Utrecht and the Erasmus Medical Center for conducting the cerebral ultrasounds, and Robbin de Goederen, Ph.D. student in the Erasmus Medical Center, for his help with collecting the cerebral ultrasounds for the validation cohort. Members of eurUS.brain are listed in the Editorial for this supplement. The members have read and approved this issue. The authors thank the European Society for Paediatric Research (ESPR) for the opportunity to present their work at the ESPR meeting in 2017 and the Pediatric Academic Society (PAS) to present a poster at the PAS meeting in 2017. Funding for this publication was provided by the European Society for Paediatric Research (ESPR). The European Union fully granted the Ph.D. position of the first author Kim Annink (HC2020-PHC18-2015-667224). Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = mar,
doi = "10.1038/s41390-020-0782-0",
language = "English",
volume = "87",
pages = "59--66",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams & Wilkins",
number = "Suppl 1",
}