The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care

Janneke M T Hendriksen; Geert-Jan Geersing; Suzanne C van Voorthuizen; Ruud Oudega; Arina J Ten Cate-Hoek; Manuela A Joore; Karel G M Moons; Hendrik Koffijberg

doi:10.1586/14737159.2015.976202

The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care

Janneke M T Hendriksen, Geert-Jan Geersing, Suzanne C van Voorthuizen, Ruud Oudega, Arina J Ten Cate-Hoek, Manuela A Joore, Karel G M Moons, Hendrik Koffijberg

Research output: Contribution to journal › Literature review › peer-review

Abstract

OBJECTIVE: Point-of-care (POC) D-dimer tests have been developed to exclude deep venous thrombosis quickly and on the spot, but are known to have lower sensitivity compared with laboratory-based tests. Their cost-effectiveness is still unknown.

METHODS: We updated and extended a previously published Markov model to assess the cost-effectiveness of POC D-dimer tests ('Simplify', 'Cardiac', 'Triage' and 'Nycocard') compared with a laboratory-based latex assay to diagnose deep venous thrombosis in primary care.

RESULTS: The 'Laboratory' strategy resulted in 6.986 quality-adjusted life years at the cost of €8354 per patient. All POC D-dimer tests resulted in health outcomes similar to the 'Laboratory' strategy. The 'Simplify' strategy maximized cost savings (-€155 [95% CI: -€246 to -€83]).

CONCLUSIONS: POC D-dimer tests yield similar health outcomes as laboratory-based testing procedures but can be performed more easily and at lower costs. Therefore, these tests are an alternative to laboratory-based testing and might be considered for exclusion of deep venous thrombosis in primary care.

Original language	English
Pages (from-to)	125-136
Number of pages	12
Journal	Expert Review of Molecular Diagnostics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1586/14737159.2015.976202
Publication status	Published - Jan 2015

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10.1586/14737159.2015.976202

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Hendriksen, J. M. T., Geersing, G.-J., van Voorthuizen, S. C., Oudega, R., Ten Cate-Hoek, A. J., Joore, M. A., Moons, K. G. M., & Koffijberg, H. (2015). The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care. Expert Review of Molecular Diagnostics, 15(1), 125-136. https://doi.org/10.1586/14737159.2015.976202

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title = "The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care",

abstract = "OBJECTIVE: Point-of-care (POC) D-dimer tests have been developed to exclude deep venous thrombosis quickly and on the spot, but are known to have lower sensitivity compared with laboratory-based tests. Their cost-effectiveness is still unknown.METHODS: We updated and extended a previously published Markov model to assess the cost-effectiveness of POC D-dimer tests ('Simplify', 'Cardiac', 'Triage' and 'Nycocard') compared with a laboratory-based latex assay to diagnose deep venous thrombosis in primary care.RESULTS: The 'Laboratory' strategy resulted in 6.986 quality-adjusted life years at the cost of €8354 per patient. All POC D-dimer tests resulted in health outcomes similar to the 'Laboratory' strategy. The 'Simplify' strategy maximized cost savings (-€155 [95% CI: -€246 to -€83]).CONCLUSIONS: POC D-dimer tests yield similar health outcomes as laboratory-based testing procedures but can be performed more easily and at lower costs. Therefore, these tests are an alternative to laboratory-based testing and might be considered for exclusion of deep venous thrombosis in primary care.",

author = "Hendriksen, {Janneke M T} and Geert-Jan Geersing and {van Voorthuizen}, {Suzanne C} and Ruud Oudega and {Ten Cate-Hoek}, {Arina J} and Joore, {Manuela A} and Moons, {Karel G M} and Hendrik Koffijberg",

year = "2015",

month = jan,

doi = "10.1586/14737159.2015.976202",

language = "English",

volume = "15",

pages = "125--136",

journal = "Expert Review of Molecular Diagnostics",

issn = "1473-7159",

publisher = "Expert Reviews Ltd.",

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}

Hendriksen, JMT, Geersing, G-J, van Voorthuizen, SC, Oudega, R, Ten Cate-Hoek, AJ, Joore, MA, Moons, KGM & Koffijberg, H 2015, 'The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care', Expert Review of Molecular Diagnostics, vol. 15, no. 1, pp. 125-136. https://doi.org/10.1586/14737159.2015.976202

The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care. / Hendriksen, Janneke M T; Geersing, Geert-Jan; van Voorthuizen, Suzanne C et al.
In: Expert Review of Molecular Diagnostics, Vol. 15, No. 1, 01.2015, p. 125-136.

Research output: Contribution to journal › Literature review › peer-review

TY - JOUR

T1 - The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care

AU - Hendriksen, Janneke M T

AU - Geersing, Geert-Jan

AU - van Voorthuizen, Suzanne C

AU - Oudega, Ruud

AU - Ten Cate-Hoek, Arina J

AU - Joore, Manuela A

AU - Moons, Karel G M

AU - Koffijberg, Hendrik

PY - 2015/1

Y1 - 2015/1

N2 - OBJECTIVE: Point-of-care (POC) D-dimer tests have been developed to exclude deep venous thrombosis quickly and on the spot, but are known to have lower sensitivity compared with laboratory-based tests. Their cost-effectiveness is still unknown.METHODS: We updated and extended a previously published Markov model to assess the cost-effectiveness of POC D-dimer tests ('Simplify', 'Cardiac', 'Triage' and 'Nycocard') compared with a laboratory-based latex assay to diagnose deep venous thrombosis in primary care.RESULTS: The 'Laboratory' strategy resulted in 6.986 quality-adjusted life years at the cost of €8354 per patient. All POC D-dimer tests resulted in health outcomes similar to the 'Laboratory' strategy. The 'Simplify' strategy maximized cost savings (-€155 [95% CI: -€246 to -€83]).CONCLUSIONS: POC D-dimer tests yield similar health outcomes as laboratory-based testing procedures but can be performed more easily and at lower costs. Therefore, these tests are an alternative to laboratory-based testing and might be considered for exclusion of deep venous thrombosis in primary care.

AB - OBJECTIVE: Point-of-care (POC) D-dimer tests have been developed to exclude deep venous thrombosis quickly and on the spot, but are known to have lower sensitivity compared with laboratory-based tests. Their cost-effectiveness is still unknown.METHODS: We updated and extended a previously published Markov model to assess the cost-effectiveness of POC D-dimer tests ('Simplify', 'Cardiac', 'Triage' and 'Nycocard') compared with a laboratory-based latex assay to diagnose deep venous thrombosis in primary care.RESULTS: The 'Laboratory' strategy resulted in 6.986 quality-adjusted life years at the cost of €8354 per patient. All POC D-dimer tests resulted in health outcomes similar to the 'Laboratory' strategy. The 'Simplify' strategy maximized cost savings (-€155 [95% CI: -€246 to -€83]).CONCLUSIONS: POC D-dimer tests yield similar health outcomes as laboratory-based testing procedures but can be performed more easily and at lower costs. Therefore, these tests are an alternative to laboratory-based testing and might be considered for exclusion of deep venous thrombosis in primary care.

U2 - 10.1586/14737159.2015.976202

DO - 10.1586/14737159.2015.976202

M3 - Literature review

C2 - 25537569

SN - 1473-7159

VL - 15

SP - 125

EP - 136

JO - Expert Review of Molecular Diagnostics

JF - Expert Review of Molecular Diagnostics

IS - 1

ER -

The cost-effectiveness of point-of-care D-dimer tests compared with a laboratory test to rule out deep venous thrombosis in primary care

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