The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

Simone Punt; Jessica M Langenhoff; H Putter; Gert Jan Fleuren; Arko Gorter; Ekaterina S Jordanova

doi:10.4161/2162402X.2014.984547

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

Simone Punt, Jessica M Langenhoff, H Putter, Gert Jan Fleuren, Arko Gorter, Ekaterina S Jordanova^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.

Original language	English
Article number	e984547
Journal	OncoImmunology
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/2162402X.2014.984547
Publication status	Published - Feb 2015
Externally published	Yes

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title = "The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review",

abstract = "Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.",

author = "Simone Punt and Langenhoff, {Jessica M} and H Putter and Fleuren, {Gert Jan} and Arko Gorter and Jordanova, {Ekaterina S}",

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doi = "10.4161/2162402X.2014.984547",

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T1 - The correlations between IL-17 vs. Th17 cells and cancer patient survival

T2 - a systematic review

AU - Punt, Simone

AU - Langenhoff, Jessica M

AU - Putter, H

AU - Fleuren, Gert Jan

AU - Gorter, Arko

AU - Jordanova, Ekaterina S

PY - 2015/2

Y1 - 2015/2

N2 - Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.

AB - Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.

U2 - 10.4161/2162402X.2014.984547

DO - 10.4161/2162402X.2014.984547

M3 - Review article

C2 - 25949881

SN - 2162-4011

VL - 4

JO - OncoImmunology

JF - OncoImmunology

IS - 2

M1 - e984547

ER -

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

Abstract

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