TY - JOUR
T1 - The Complex Relationship Between Serum Uric Acid, Endothelial Function and Small Vessel Remodeling in Humans
AU - Masi, Stefano
AU - Georgiopoulos, Georgios
AU - Alexopoulos, George
AU - Pateras, Konstantinos
AU - Rosada, Javier
AU - Seravalle, Gino
AU - De Ciuceis, Carolina
AU - Taddei, Stefano
AU - Borghi, Claudio
AU - Grassi, Guido
AU - Rizzoni, Damiano
AU - Virdis, Agostino
AU - The Study Groups On The Uric Acid Right For heArt Health Urrah, null
AU - Micro-And Macro-Circulation Of The Italian Society Of Hypertension Siia, null
N1 - Publisher Copyright:
© 2020 by the authors.
PY - 2020/7
Y1 - 2020/7
N2 - AIMS: The relationship between serum uric acid (SUA) and microvascular remodeling in humans remains largely unexplored. We assessed whether SUA provides additional information on the severity of microvascular remodeling than that obtained from the European Heart Score (HS), the patterns of microvascular remodeling associated with changes in SUA levels and the mediation by endothelial function and nitric oxide (NO) availability on this relationship.METHODS: A total of 162 patients included in the microvascular dataset of the Italian Society of Hypertension with available information on SUA, media-to-lumen (M/L) ratio, media cross-sectional area (MCSA), endothelial function, NO availability and HS were included in the analysis. The top tertile of M/L ratio and MCSA were used to define severe microvascular remodeling.RESULTS: A U-shaped association was observed between SUA and both M/L ratio and MCSA. Adjustment for HS did not affect these associations. SUA was able to reclassify a significant number of subjects without, and with, severe M/L ratio and MCSA remodeling over the HS alone. The microvascular remodeling associated with SUA levels presented a predominant hypertrophic pattern. SUA was inversely associated with endothelial function and NO availability. Structural equation modeling analysis controlling for the HS suggested that the association of SUA with M/L ratio and MCSA was mediated through changes in endothelial function and NO availability.CONCLUSIONS: The addition of SUA to the HS improves the identification of subjects with greater microvascular remodeling. The relationship between SUA and microvascular remodeling is mediated by endothelial function and NO availability.
AB - AIMS: The relationship between serum uric acid (SUA) and microvascular remodeling in humans remains largely unexplored. We assessed whether SUA provides additional information on the severity of microvascular remodeling than that obtained from the European Heart Score (HS), the patterns of microvascular remodeling associated with changes in SUA levels and the mediation by endothelial function and nitric oxide (NO) availability on this relationship.METHODS: A total of 162 patients included in the microvascular dataset of the Italian Society of Hypertension with available information on SUA, media-to-lumen (M/L) ratio, media cross-sectional area (MCSA), endothelial function, NO availability and HS were included in the analysis. The top tertile of M/L ratio and MCSA were used to define severe microvascular remodeling.RESULTS: A U-shaped association was observed between SUA and both M/L ratio and MCSA. Adjustment for HS did not affect these associations. SUA was able to reclassify a significant number of subjects without, and with, severe M/L ratio and MCSA remodeling over the HS alone. The microvascular remodeling associated with SUA levels presented a predominant hypertrophic pattern. SUA was inversely associated with endothelial function and NO availability. Structural equation modeling analysis controlling for the HS suggested that the association of SUA with M/L ratio and MCSA was mediated through changes in endothelial function and NO availability.CONCLUSIONS: The addition of SUA to the HS improves the identification of subjects with greater microvascular remodeling. The relationship between SUA and microvascular remodeling is mediated by endothelial function and NO availability.
KW - Endothelial function
KW - Microvascular
KW - Remodeling
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=85107738584&partnerID=8YFLogxK
U2 - 10.3390/jcm9072027
DO - 10.3390/jcm9072027
M3 - Article
C2 - 32605201
SN - 2077-0383
VL - 9
JO - Journal of Clinical medicine
JF - Journal of Clinical medicine
IS - 7
M1 - 2027
ER -