The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people

Nahid Ramezani-Jolfaie, Shiva Aghaei, Ehsan Farashahi Yazd, Ali Moradi, Hassan Mozaffari-Khosravi, Mojgan Amiri, Hamidreza Raeisi-Dehkordi, Fatemeh Moghtaderi, Alireza Zimorovat, Seyed Ali Yasini Ardakani, Amin Salehi-Abargouei*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week of the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: ApoA-1, and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: ApoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalJournal of Cardiovascular and Thoracic Research
Volume12
Issue number3
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Canola Oil
  • Cholesterol Ester Transfer Proteins
  • Diabetes Mellitus
  • Polymorphism
  • Sesame Oil
  • Sesame-Canola Oil

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