TY - JOUR
T1 - The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people
AU - Ramezani-Jolfaie, Nahid
AU - Aghaei, Shiva
AU - Yazd, Ehsan Farashahi
AU - Moradi, Ali
AU - Mozaffari-Khosravi, Hassan
AU - Amiri, Mojgan
AU - Raeisi-Dehkordi, Hamidreza
AU - Moghtaderi, Fatemeh
AU - Zimorovat, Alireza
AU - Ardakani, Seyed Ali Yasini
AU - Salehi-Abargouei, Amin
N1 - Publisher Copyright:
© 2020 The Author (s).
PY - 2020
Y1 - 2020
N2 - Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week of the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: ApoA-1, and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: ApoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.
AB - Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB polymorphism on metabolic profiles were modified by dietary plant oils. Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week of the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning and at the end of each intervention period for biochemical analysis. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: ApoA-1, and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB, apoB: ApoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes patients. No independent or combined effects of dietary oils and genotypes on outcomes were found in healthy people. Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.
KW - Canola Oil
KW - Cholesterol Ester Transfer Proteins
KW - Diabetes Mellitus
KW - Polymorphism
KW - Sesame Oil
KW - Sesame-Canola Oil
UR - http://www.scopus.com/inward/record.url?scp=85106423524&partnerID=8YFLogxK
U2 - 10.34172/jcvtr.2020.32
DO - 10.34172/jcvtr.2020.32
M3 - Article
AN - SCOPUS:85106423524
SN - 2008-5117
VL - 12
SP - 185
EP - 194
JO - Journal of Cardiovascular and Thoracic Research
JF - Journal of Cardiovascular and Thoracic Research
IS - 3
ER -