The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse

Lucas J T Kaaij; Fabio Mohn; Robin H van der Weide; Elzo de Wit; Marc Bühler

doi:10.1016/j.cell.2019.08.007

The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse

Lucas J T Kaaij^*, Fabio Mohn^*, Robin H van der Weide, Elzo de Wit, Marc Bühler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ChAHP is a local regulator of chromatin architecture that competes with CTCF for chromatin binding, thereby affecting TAD boundaries and cohesin-mediated chromatin looping, and shows preferential specificity for binding at evolutionarily younger SINE elements.

Original language	English
Pages (from-to)	1437-1451.e14
Journal	Cell
Volume	178
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2019.08.007
Publication status	Published - 5 Sept 2019
Externally published	Yes

Keywords

3D chromatin architecture
ADNP
CHD4
CTCF
ChAHP
Helsmoortel-van-der-Aa syndrome
Hi-C
SINE B2 transposable element
chromatin looping
cohesin

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@article{335a0090791b4fe7b145ce21d8fed1ab,

title = "The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse",

abstract = "ChAHP is a local regulator of chromatin architecture that competes with CTCF for chromatin binding, thereby affecting TAD boundaries and cohesin-mediated chromatin looping, and shows preferential specificity for binding at evolutionarily younger SINE elements.",

keywords = "3D chromatin architecture, ADNP, CHD4, CTCF, ChAHP, Helsmoortel-van-der-Aa syndrome, Hi-C, SINE B2 transposable element, chromatin looping, cohesin",

author = "Kaaij, {Lucas J T} and Fabio Mohn and {van der Weide}, {Robin H} and {de Wit}, Elzo and Marc B{\"u}hler",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "5",

doi = "10.1016/j.cell.2019.08.007",

language = "English",

volume = "178",

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TY - JOUR

T1 - The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse

AU - Kaaij, Lucas J T

AU - Mohn, Fabio

AU - van der Weide, Robin H

AU - de Wit, Elzo

AU - Bühler, Marc

PY - 2019/9/5

Y1 - 2019/9/5

N2 - ChAHP is a local regulator of chromatin architecture that competes with CTCF for chromatin binding, thereby affecting TAD boundaries and cohesin-mediated chromatin looping, and shows preferential specificity for binding at evolutionarily younger SINE elements.

AB - ChAHP is a local regulator of chromatin architecture that competes with CTCF for chromatin binding, thereby affecting TAD boundaries and cohesin-mediated chromatin looping, and shows preferential specificity for binding at evolutionarily younger SINE elements.

KW - 3D chromatin architecture

KW - ADNP

KW - CHD4

KW - CTCF

KW - ChAHP

KW - Helsmoortel-van-der-Aa syndrome

KW - Hi-C

KW - SINE B2 transposable element

KW - chromatin looping

KW - cohesin

UR - http://www.scopus.com/inward/record.url?scp=85071315791&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.08.007

DO - 10.1016/j.cell.2019.08.007

M3 - Article

C2 - 31491387

SN - 0092-8674

VL - 178

SP - 1437-1451.e14

JO - Cell

JF - Cell

IS - 6

ER -

The ChAHP Complex Counteracts Chromatin Looping at CTCF Sites that Emerged from SINE Expansions in Mouse

Abstract

Keywords

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