TY - JOUR
T1 - The cellular composition and function of the bone marrow niche after allogeneic hematopoietic cell transplantation
AU - Peci, Flavia
AU - Dekker, Linde
AU - Pagliaro, Anna
AU - van Boxtel, Ruben
AU - Nierkens, Stefan
AU - Belderbos, Mirjam
N1 - Funding Information:
MEB receives financial support by research grants of the Dutch National Research. Council (VI.Veni.202.021), by a Leukemia Fellowship Grant of the European Society for Blood and Marrow Transplantation and by a John Hansen Research Grant of the DKMS. These funding bodies had no role in the design of the study, nor in the collection, analysis, and interpretation of the data, nor in writing the manuscript.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/9
Y1 - 2022/9
N2 - Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with a variety of malignant and non-malignant diseases. Despite its life-saving potential, HCT is associated with significant morbidity and mortality. Reciprocal interactions between hematopoietic stem cells (HSCs) and their surrounding bone marrow (BM) niche regulate HSC function during homeostatic hematopoiesis as well as regeneration. However, current pre-HCT conditioning regimens, which consist of high-dose chemotherapy and/or irradiation, cause substantial short- and long-term toxicity to the BM niche. This damage may negatively affect HSC function, impair hematopoietic regeneration after HCT and predispose to HCT-related morbidity and mortality. In this review, we summarize current knowledge on the cellular composition of the human BM niche after HCT. We describe how pre-HCT conditioning affects the cell types in the niche, including endothelial cells, mesenchymal stromal cells, osteoblasts, adipocytes, and neurons. Finally, we discuss therapeutic strategies to prevent or repair conditioning-induced niche damage, which may promote hematopoietic recovery and improve HCT outcome.
AB - Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with a variety of malignant and non-malignant diseases. Despite its life-saving potential, HCT is associated with significant morbidity and mortality. Reciprocal interactions between hematopoietic stem cells (HSCs) and their surrounding bone marrow (BM) niche regulate HSC function during homeostatic hematopoiesis as well as regeneration. However, current pre-HCT conditioning regimens, which consist of high-dose chemotherapy and/or irradiation, cause substantial short- and long-term toxicity to the BM niche. This damage may negatively affect HSC function, impair hematopoietic regeneration after HCT and predispose to HCT-related morbidity and mortality. In this review, we summarize current knowledge on the cellular composition of the human BM niche after HCT. We describe how pre-HCT conditioning affects the cell types in the niche, including endothelial cells, mesenchymal stromal cells, osteoblasts, adipocytes, and neurons. Finally, we discuss therapeutic strategies to prevent or repair conditioning-induced niche damage, which may promote hematopoietic recovery and improve HCT outcome.
UR - http://www.scopus.com/inward/record.url?scp=85131727239&partnerID=8YFLogxK
U2 - 10.1038/s41409-022-01728-0
DO - 10.1038/s41409-022-01728-0
M3 - Review article
C2 - 35690693
AN - SCOPUS:85131727239
SN - 0268-3369
VL - 57
SP - 1357
EP - 1364
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 9
ER -