TY - JOUR
T1 - The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
AU - Bergmann, Manuela M.
AU - Rehm, Juergen
AU - Klipstein-Grobusch, Kerstin
AU - Boeing, Heiner
AU - Schuetze, Madlen
AU - Drogan, Dagmar
AU - Overvad, Kim
AU - Tjonneland, Anne
AU - Halkjaer, Jytte
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon, Francoise
AU - Teucher, Birgit
AU - Kaaks, Rudolph
AU - Trichopoulou, Antonia
AU - Benetou, Vassiliki
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Beulens, Joline W. J.
AU - Luisa Redondo, Maria
AU - Duell, Eric J.
AU - Molina-Montes, Esther
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Arriola, Larraitz
AU - Allen, Naomi E.
AU - Crowe, Francesca L.
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Romaguera, Dora
AU - Wark, Petra A.
AU - Romieu, Isabelle
AU - Nunes, Luciana
AU - Riboli, Elio
AU - Ferrari, Pietro
PY - 2013/12
Y1 - 2013/12
N2 - Methods Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrolment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up.Results The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (> 5 drinks/day for men and > 2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (1 and 0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrolment.Conclusions Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life.
AB - Methods Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrolment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up.Results The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (> 5 drinks/day for men and > 2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (1 and 0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrolment.Conclusions Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life.
KW - Prospective study
KW - lifetime alcohol use
KW - cause-specific mortality
KW - EPIC
KW - CARDIOVASCULAR-DISEASE
KW - COMPETING RISKS
KW - CONSUMPTION
KW - MORTALITY
KW - DRINKING
KW - HEALTH
KW - METAANALYSIS
KW - MORBIDITY
KW - CONFOUNDERS
KW - POPULATIONS
U2 - 10.1093/ije/dyt154
DO - 10.1093/ije/dyt154
M3 - Article
C2 - 24415611
SN - 0300-5771
VL - 42
SP - 1772
EP - 1790
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 6
ER -