The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Anouk W M A Schaeffers; Anouk V M Burger; Charlotte W Duinkerken; Klaske E van Sluis; Jan Paul de Boer; Lisette van der Molen; Alex E Hoetink; Abrahim Al-Mamgani; Katarzyna Jóźwiak; Lot A Devriese; Remco de Bree; Charlotte L Zuur

doi:10.1002/hed.27907

The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Anouk W M A Schaeffers^*, Anouk V M Burger, Charlotte W Duinkerken, Klaske E van Sluis, Jan Paul de Boer, Lisette van der Molen, Alex E Hoetink, Abrahim Al-Mamgani, Katarzyna Jóźwiak, Lot A Devriese, Remco de Bree, Charlotte L Zuur

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Downloads (Pure)

Abstract

INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.

MATERIALS AND METHODS: LSMI was assessed using routine pre-treatment CT scans. Pure tone audiometry was performed at baseline and at follow-up to assess treatment-related SNHL. Linear mixed models were used to reveal a potential association between the continuous variable LSMI and SNHL.

RESULTS: This retrospective cohort study included 81 patients and found a significant association between low LSMI and increased treatment-related SNHL at pure tone frequencies vital for the perception of speech (averaged of 1, 2, and 4 kHz) (p = 0.048).

CONCLUSIONS: HNSCC patients with low LSMI suffer increased treatment-related SNHL upon cisplatin-based CRT.

Original language	English
Pages (from-to)	189-200
Number of pages	12
Journal	Head & neck
Volume	47
Issue number	1
Early online date	2 Aug 2024
DOIs	https://doi.org/10.1002/hed.27907
Publication status	Published - Jan 2025

Keywords

chemoradiotherapy
cisplatin
head and neck
hearing loss
ototoxicity
skeletal muscle mass

Access to Document

10.1002/hed.27907Licence: CC BY-NC-ND

Head Neck - 2024 - Schaeffers - The association between skeletal muscle mass and sensorineural hearing loss uponFinal published version, 1,000 KBLicence: CC BY-NC-ND

Cite this

Schaeffers, A. W. M. A., Burger, A. V. M., Duinkerken, C. W., van Sluis, K. E., de Boer, J. P., van der Molen, L., Hoetink, A. E., Al-Mamgani, A., Jóźwiak, K., Devriese, L. A., de Bree, R., & Zuur, C. L. (2025). The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma. Head & neck, 47(1), 189-200. https://doi.org/10.1002/hed.27907

@article{0445ef8492644486bf32e0ae0037b72d,

title = "The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma",

abstract = "INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.MATERIALS AND METHODS: LSMI was assessed using routine pre-treatment CT scans. Pure tone audiometry was performed at baseline and at follow-up to assess treatment-related SNHL. Linear mixed models were used to reveal a potential association between the continuous variable LSMI and SNHL.RESULTS: This retrospective cohort study included 81 patients and found a significant association between low LSMI and increased treatment-related SNHL at pure tone frequencies vital for the perception of speech (averaged of 1, 2, and 4 kHz) (p = 0.048).CONCLUSIONS: HNSCC patients with low LSMI suffer increased treatment-related SNHL upon cisplatin-based CRT.",

keywords = "chemoradiotherapy, cisplatin, head and neck, hearing loss, ototoxicity, skeletal muscle mass",

author = "Schaeffers, {Anouk W M A} and Burger, {Anouk V M} and Duinkerken, {Charlotte W} and {van Sluis}, {Klaske E} and {de Boer}, {Jan Paul} and {van der Molen}, Lisette and Hoetink, {Alex E} and Abrahim Al-Mamgani and Katarzyna J{\'o}{\'z}wiak and Devriese, {Lot A} and {de Bree}, Remco and Zuur, {Charlotte L}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Head & Neck published by Wiley Periodicals LLC.",

year = "2025",

month = jan,

doi = "10.1002/hed.27907",

language = "English",

volume = "47",

pages = "189--200",

journal = "Head & neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Schaeffers, AWMA, Burger, AVM, Duinkerken, CW, van Sluis, KE, de Boer, JP, van der Molen, L, Hoetink, AE, Al-Mamgani, A, Jóźwiak, K, Devriese, LA, de Bree, R & Zuur, CL 2025, 'The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma', Head & neck, vol. 47, no. 1, pp. 189-200. https://doi.org/10.1002/hed.27907

The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma. / Schaeffers, Anouk W M A; Burger, Anouk V M; Duinkerken, Charlotte W et al.
In: Head & neck, Vol. 47, No. 1, 01.2025, p. 189-200.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

AU - Schaeffers, Anouk W M A

AU - Burger, Anouk V M

AU - Duinkerken, Charlotte W

AU - van Sluis, Klaske E

AU - de Boer, Jan Paul

AU - van der Molen, Lisette

AU - Hoetink, Alex E

AU - Al-Mamgani, Abrahim

AU - Jóźwiak, Katarzyna

AU - Devriese, Lot A

AU - de Bree, Remco

AU - Zuur, Charlotte L

PY - 2025/1

Y1 - 2025/1

N2 - INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.MATERIALS AND METHODS: LSMI was assessed using routine pre-treatment CT scans. Pure tone audiometry was performed at baseline and at follow-up to assess treatment-related SNHL. Linear mixed models were used to reveal a potential association between the continuous variable LSMI and SNHL.RESULTS: This retrospective cohort study included 81 patients and found a significant association between low LSMI and increased treatment-related SNHL at pure tone frequencies vital for the perception of speech (averaged of 1, 2, and 4 kHz) (p = 0.048).CONCLUSIONS: HNSCC patients with low LSMI suffer increased treatment-related SNHL upon cisplatin-based CRT.

AB - INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.MATERIALS AND METHODS: LSMI was assessed using routine pre-treatment CT scans. Pure tone audiometry was performed at baseline and at follow-up to assess treatment-related SNHL. Linear mixed models were used to reveal a potential association between the continuous variable LSMI and SNHL.RESULTS: This retrospective cohort study included 81 patients and found a significant association between low LSMI and increased treatment-related SNHL at pure tone frequencies vital for the perception of speech (averaged of 1, 2, and 4 kHz) (p = 0.048).CONCLUSIONS: HNSCC patients with low LSMI suffer increased treatment-related SNHL upon cisplatin-based CRT.

KW - chemoradiotherapy

KW - cisplatin

KW - head and neck

KW - hearing loss

KW - ototoxicity

KW - skeletal muscle mass

UR - http://www.scopus.com/inward/record.url?scp=85200237721&partnerID=8YFLogxK

U2 - 10.1002/hed.27907

DO - 10.1002/hed.27907

M3 - Article

C2 - 39096016

SN - 1043-3074

VL - 47

SP - 189

EP - 200

JO - Head & neck

JF - Head & neck

IS - 1

ER -

The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this