TY - JOUR
T1 - The association between postoperative complications and long-term survival after esophagectomy
T2 - a multicenter cohort study
AU - Fransen, Laura F C
AU - Verhoeven, Rob H A
AU - Janssen, Thijs H J B
AU - van Det, Marc J
AU - Gisbertz, Suzanne S
AU - van Hillegersberg, Richard
AU - Klarenbeek, Bastiaan
AU - Kouwenhoven, Ewout A
AU - Nieuwenhuijzen, Grard A P
AU - Rosman, Camiel
AU - Ruurda, Jelle P
AU - van Berge Henegouwen, Mark I
AU - Luyer, Misha D P
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved.
PY - 2023/6
Y1 - 2023/6
N2 - Conflicting results are reported on the association between post-esophagectomy complications and long-term survival. This multicenter study assesses the association between complications after an esophagectomy and long-term overall survival. Five Dutch high-volume centers collected data from consecutive patients undergoing esophagectomy between 2010 and 2016 and merged these with long-term survival data from the Netherlands Cancer Registry. Exclusion criteria were non-curative resections and 90-day mortality, among others. Primary outcome was overall survival related to the presence of a postoperative complication in general. Secondary outcomes analyzed the presence of anastomotic leakage and cardiopulmonary complications. Propensity score matching was performed and the outcomes were analyzed via Log-Rank test and Kaplan Meier analysis. Among the 1225 patients included, a complicated course occurred in 719 patients (59.0%). After matching for baseline characteristics, 455 pairs were successfully balanced. Patients with an uncomplicated postoperative course had a 5-year overall survival of 51.7% versus 44.4% in patients with complications (P = 0.011). Anastomotic leakage occurred in 18.4% (n = 226), and in 208 matched pairs, it was shown that the 5-year overall survival was 57.2% in patients without anastomotic leakage versus 44.0% in patients with anastomotic leakage (P = 0.005). Overall cardiopulmonary complication rate was 37.1% (n = 454), and in 363 matched pairs, the 5-year overall survival was 52.1% in patients without cardiopulmonary complications versus 45.3% in patients with cardiopulmonary complications (P = 0.019). Overall postoperative complication rate, anastomotic leakage, and cardiopulmonary complications were associated with a decreased long-term survival after an esophagectomy. Efforts to reduce complications might further improve the overall survival for patients treated for esophageal carcinoma.
AB - Conflicting results are reported on the association between post-esophagectomy complications and long-term survival. This multicenter study assesses the association between complications after an esophagectomy and long-term overall survival. Five Dutch high-volume centers collected data from consecutive patients undergoing esophagectomy between 2010 and 2016 and merged these with long-term survival data from the Netherlands Cancer Registry. Exclusion criteria were non-curative resections and 90-day mortality, among others. Primary outcome was overall survival related to the presence of a postoperative complication in general. Secondary outcomes analyzed the presence of anastomotic leakage and cardiopulmonary complications. Propensity score matching was performed and the outcomes were analyzed via Log-Rank test and Kaplan Meier analysis. Among the 1225 patients included, a complicated course occurred in 719 patients (59.0%). After matching for baseline characteristics, 455 pairs were successfully balanced. Patients with an uncomplicated postoperative course had a 5-year overall survival of 51.7% versus 44.4% in patients with complications (P = 0.011). Anastomotic leakage occurred in 18.4% (n = 226), and in 208 matched pairs, it was shown that the 5-year overall survival was 57.2% in patients without anastomotic leakage versus 44.0% in patients with anastomotic leakage (P = 0.005). Overall cardiopulmonary complication rate was 37.1% (n = 454), and in 363 matched pairs, the 5-year overall survival was 52.1% in patients without cardiopulmonary complications versus 45.3% in patients with cardiopulmonary complications (P = 0.019). Overall postoperative complication rate, anastomotic leakage, and cardiopulmonary complications were associated with a decreased long-term survival after an esophagectomy. Efforts to reduce complications might further improve the overall survival for patients treated for esophageal carcinoma.
KW - Anastomotic Leak/epidemiology
KW - Carcinoma, Squamous Cell/surgery
KW - Cohort Studies
KW - Esophageal Neoplasms/pathology
KW - Esophagectomy/adverse effects
KW - Humans
KW - Postoperative Complications/epidemiology
KW - Retrospective Studies
KW - esophagectomy
KW - long-term survival
KW - postoperative complication
UR - http://www.scopus.com/inward/record.url?scp=85160870048&partnerID=8YFLogxK
U2 - 10.1093/dote/doac086
DO - 10.1093/dote/doac086
M3 - Article
C2 - 36477850
SN - 1120-8694
VL - 36
SP - 1
EP - 11
JO - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
JF - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
IS - 6
M1 - doac086
ER -