The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy

Charlotte Falke; Fatma Karapinar; Marcel Bouvy; Mariëlle Emmelot; Svetlana Belitser; Benoit Boland; Denis O'Mahony; Kevin D Murphy; Moa Haller; Paola Salari; Matthias Schwenkglenks; Nicolas Rodondi; Toine Egberts; Wilma Knol

doi:10.1007/s41999-024-01036-4

The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy

Charlotte Falke
, Fatma Karapinar
, Marcel Bouvy
, Mariëlle Emmelot
, Svetlana Belitser
, Benoit Boland
, Denis O'Mahony
, Kevin D Murphy
, Moa Haller
, Paola Salari
, Matthias Schwenkglenks
, Nicolas Rodondi
, Toine Egberts
, Wilma Knol

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aim: To explore the association between medication use-related factors and quality of life in older hospitalised patients with polypharmacy. Findings: Hyperpolypharmacy, a high anticholinergic and sedative burden, presence of multiple prescribing omissions (based on START criteria), the use of opioids, antibiotics and benzodiazepines, and high medication complexity were associated with a lower quality of life. Message: Due to the association with quality of life, evaluating medication use-related factors, especially medication complexity as a novel factor, is important for hospitalised older patients with (hyper)polypharmacy.

Original language	English
Pages (from-to)	1713–1723
Number of pages	11
Journal	European Geriatric Medicine
Volume	15
Issue number	6
Early online date	20 Aug 2024
DOIs	https://doi.org/10.1007/s41999-024-01036-4
Publication status	Published - Dec 2024

Keywords

HRQoL
Quality of life
Medication use
Medication complexity
Polypharmacy

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Falke, C., Karapinar, F., Bouvy, M., Emmelot, M., Belitser, S., Boland, B., O'Mahony, D., Murphy, K. D., Haller, M., Salari, P., Schwenkglenks, M., Rodondi, N., Egberts, T., & Knol, W. (2024). The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy. European Geriatric Medicine, 15(6), 1713–1723. https://doi.org/10.1007/s41999-024-01036-4

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title = "The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy",

abstract = "Aim: To explore the association between medication use-related factors and quality of life in older hospitalised patients with polypharmacy. Findings: Hyperpolypharmacy, a high anticholinergic and sedative burden, presence of multiple prescribing omissions (based on START criteria), the use of opioids, antibiotics and benzodiazepines, and high medication complexity were associated with a lower quality of life. Message: Due to the association with quality of life, evaluating medication use-related factors, especially medication complexity as a novel factor, is important for hospitalised older patients with (hyper)polypharmacy.",

keywords = "HRQoL, Quality of life, Medication use, Medication complexity, Polypharmacy",

author = "Charlotte Falke and Fatma Karapinar and Marcel Bouvy and Mari{\"e}lle Emmelot and Svetlana Belitser and Benoit Boland and Denis O'Mahony and Murphy, \{Kevin D\} and Moa Haller and Paola Salari and Matthias Schwenkglenks and Nicolas Rodondi and Toine Egberts and Wilma Knol",

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doi = "10.1007/s41999-024-01036-4",

language = "English",

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Falke, C, Karapinar, F, Bouvy, M, Emmelot, M, Belitser, S, Boland, B, O'Mahony, D, Murphy, KD, Haller, M, Salari, P, Schwenkglenks, M, Rodondi, N, Egberts, T & Knol, W 2024, 'The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy', European Geriatric Medicine, vol. 15, no. 6, pp. 1713–1723. https://doi.org/10.1007/s41999-024-01036-4

TY - JOUR

T1 - The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy

AU - Falke, Charlotte

AU - Karapinar, Fatma

AU - Bouvy, Marcel

AU - Emmelot, Mariëlle

AU - Belitser, Svetlana

AU - Boland, Benoit

AU - O'Mahony, Denis

AU - Murphy, Kevin D

AU - Haller, Moa

AU - Salari, Paola

AU - Schwenkglenks, Matthias

AU - Rodondi, Nicolas

AU - Egberts, Toine

AU - Knol, Wilma

PY - 2024/12

Y1 - 2024/12

N2 - Aim: To explore the association between medication use-related factors and quality of life in older hospitalised patients with polypharmacy. Findings: Hyperpolypharmacy, a high anticholinergic and sedative burden, presence of multiple prescribing omissions (based on START criteria), the use of opioids, antibiotics and benzodiazepines, and high medication complexity were associated with a lower quality of life. Message: Due to the association with quality of life, evaluating medication use-related factors, especially medication complexity as a novel factor, is important for hospitalised older patients with (hyper)polypharmacy.

AB - Aim: To explore the association between medication use-related factors and quality of life in older hospitalised patients with polypharmacy. Findings: Hyperpolypharmacy, a high anticholinergic and sedative burden, presence of multiple prescribing omissions (based on START criteria), the use of opioids, antibiotics and benzodiazepines, and high medication complexity were associated with a lower quality of life. Message: Due to the association with quality of life, evaluating medication use-related factors, especially medication complexity as a novel factor, is important for hospitalised older patients with (hyper)polypharmacy.

KW - HRQoL

KW - Quality of life

KW - Medication use

KW - Medication complexity

KW - Polypharmacy

UR - https://www.scopus.com/pages/publications/85201602172

U2 - 10.1007/s41999-024-01036-4

DO - 10.1007/s41999-024-01036-4

M3 - Article

C2 - 39162972

SN - 1878-7649

VL - 15

SP - 1713

EP - 1723

JO - European Geriatric Medicine

JF - European Geriatric Medicine

IS - 6

ER -

The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy

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