The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study

I. Wilting; A.C.G. Egberts; K.L.L. Movig; J.H.M. van Laarhoven; E.R. Heerdink; W.A. Nolen

doi:10.1055/s-2008-1058105

The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study

I. Wilting, A.C.G. Egberts, K.L.L. Movig, J.H.M. van Laarhoven, E.R. Heerdink, W.A. Nolen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: A previous Study aimed at revealing the prevalence and determinants Of lithium induced polyuria Suggested an increased risk of polyuria (urine volume >= 3L/24h) in those using serotonergic antidepressants next to lithium.

Objective: The objective of our study was to re-evaluate this secondary finding in another study population.

Methods: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.

Results: We included 116 patients, twelve (26 %) of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (odds ratio 2.86; 95 % confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.

Conclusion: Our results Confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polytiria in patients using lithium and when choosing an antidepressant in patients using lithium.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Pharmacopsychiatry
Volume	41
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1058105
Publication status	Published - Jul 2008

Keywords

LONG-TERM LITHIUM
BIPOLAR DISORDER
URINARY-INCONTINENCE
WATER-INTOXICATION
5-HT4 RECEPTORS
RISK-FACTORS
THERAPY
HYPONATREMIA
RISPERIDONE
VENLAFAXINE

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title = "The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study",

abstract = "Background: A previous Study aimed at revealing the prevalence and determinants Of lithium induced polyuria Suggested an increased risk of polyuria (urine volume >= 3L/24h) in those using serotonergic antidepressants next to lithium.Objective: The objective of our study was to re-evaluate this secondary finding in another study population.Methods: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.Results: We included 116 patients, twelve (26 %) of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (odds ratio 2.86; 95 % confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.Conclusion: Our results Confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polytiria in patients using lithium and when choosing an antidepressant in patients using lithium.",

keywords = "LONG-TERM LITHIUM, BIPOLAR DISORDER, URINARY-INCONTINENCE, WATER-INTOXICATION, 5-HT4 RECEPTORS, RISK-FACTORS, THERAPY, HYPONATREMIA, RISPERIDONE, VENLAFAXINE",

author = "I. Wilting and A.C.G. Egberts and K.L.L. Movig and {van Laarhoven}, J.H.M. and E.R. Heerdink and W.A. Nolen",

year = "2008",

month = jul,

doi = "10.1055/s-2008-1058105",

language = "English",

volume = "41",

pages = "129--133",

journal = "Pharmacopsychiatry",

issn = "0176-3679",

publisher = "Georg Thieme Verlag",

number = "4",

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T1 - The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study

AU - Wilting, I.

AU - Egberts, A.C.G.

AU - Movig, K.L.L.

AU - van Laarhoven, J.H.M.

AU - Heerdink, E.R.

AU - Nolen, W.A.

PY - 2008/7

Y1 - 2008/7

N2 - Background: A previous Study aimed at revealing the prevalence and determinants Of lithium induced polyuria Suggested an increased risk of polyuria (urine volume >= 3L/24h) in those using serotonergic antidepressants next to lithium.Objective: The objective of our study was to re-evaluate this secondary finding in another study population.Methods: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.Results: We included 116 patients, twelve (26 %) of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (odds ratio 2.86; 95 % confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.Conclusion: Our results Confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polytiria in patients using lithium and when choosing an antidepressant in patients using lithium.

AB - Background: A previous Study aimed at revealing the prevalence and determinants Of lithium induced polyuria Suggested an increased risk of polyuria (urine volume >= 3L/24h) in those using serotonergic antidepressants next to lithium.Objective: The objective of our study was to re-evaluate this secondary finding in another study population.Methods: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined.Results: We included 116 patients, twelve (26 %) of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (odds ratio 2.86; 95 % confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics.Conclusion: Our results Confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polytiria in patients using lithium and when choosing an antidepressant in patients using lithium.

KW - LONG-TERM LITHIUM

KW - BIPOLAR DISORDER

KW - URINARY-INCONTINENCE

KW - WATER-INTOXICATION

KW - 5-HT4 RECEPTORS

KW - RISK-FACTORS

KW - THERAPY

KW - HYPONATREMIA

KW - RISPERIDONE

KW - VENLAFAXINE

U2 - 10.1055/s-2008-1058105

DO - 10.1055/s-2008-1058105

M3 - Article

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SN - 0176-3679

VL - 41

SP - 129

EP - 133

JO - Pharmacopsychiatry

JF - Pharmacopsychiatry

IS - 4

ER -

The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study

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Keywords

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