The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort

Ali Arabkhazaeli; Fariba Ahmadizar; Maarten Leusink; Hubertus G M Arets; Jan A M Raaijmakers; Cuno S P M Uiterwaal; Cornelis K van der Ent; Anke-Hilse Maitland-vd Zee; Susanne J H Vijverberg

doi:10.1111/pai.12824

The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort

Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S P M Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-vd Zee, Susanne J H Vijverberg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.

METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. The GRS was tested in children who participated in a population-based newborn cohort (WHISTLER) and were followed from birth to school age. Logistic regression analysis was used to study the association between the GRS and the parental-reported allergies at age 5 (based on a reported allergy to ≥1 of the following allergens: pollen, house dust mites, or pets). A Cox regression model was used to study the association between GRS and a physician-diagnosed allergy during follow-up (allergic conjunctivitis, allergic rhinitis, and eczema/dermatitis). Cohen's kappa coefficient was calculated to study the agreement between physician-diagnosed allergy and parental-reported allergy at age 5.

RESULTS: The GRS was significantly associated with parental-reported allergy (odds ratio: 15.9, 95% confidence interval (CI): 1.07-233.73) at age 5, as well as with a physician-diagnosed allergy during follow-up (hazard ratio: 1.89, 95% CI: 1.05-3.41). The overall agreement between physician-diagnosed and parental-reported allergies was 70.5% (kappa: 0.10, 95% CI: 0.03-0.18).

CONCLUSIONS: An adult-derived GRS for allergy predicts the risk of developing allergies in childhood.

Original language	English
Pages (from-to)	72-77
Number of pages	6
Journal	Pediatric Allergy and Immunology
Volume	29
Issue number	1
Early online date	2017
DOIs	https://doi.org/10.1111/pai.12824
Publication status	Published - Feb 2018

Keywords

allergy
birth cohort
genetics
risk score

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Arabkhazaeli, A., Ahmadizar, F., Leusink, M., Arets, H. G. M., Raaijmakers, J. A. M., Uiterwaal, C. S. P. M., van der Ent, C. K., Maitland-vd Zee, A.-H., & Vijverberg, S. J. H. (2018). The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort. Pediatric Allergy and Immunology, 29(1), 72-77. https://doi.org/10.1111/pai.12824

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title = "The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort",

abstract = "BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. The GRS was tested in children who participated in a population-based newborn cohort (WHISTLER) and were followed from birth to school age. Logistic regression analysis was used to study the association between the GRS and the parental-reported allergies at age 5 (based on a reported allergy to ≥1 of the following allergens: pollen, house dust mites, or pets). A Cox regression model was used to study the association between GRS and a physician-diagnosed allergy during follow-up (allergic conjunctivitis, allergic rhinitis, and eczema/dermatitis). Cohen's kappa coefficient was calculated to study the agreement between physician-diagnosed allergy and parental-reported allergy at age 5.RESULTS: The GRS was significantly associated with parental-reported allergy (odds ratio: 15.9, 95% confidence interval (CI): 1.07-233.73) at age 5, as well as with a physician-diagnosed allergy during follow-up (hazard ratio: 1.89, 95% CI: 1.05-3.41). The overall agreement between physician-diagnosed and parental-reported allergies was 70.5% (kappa: 0.10, 95% CI: 0.03-0.18).CONCLUSIONS: An adult-derived GRS for allergy predicts the risk of developing allergies in childhood.",

keywords = "allergy, birth cohort, genetics, risk score",

author = "Ali Arabkhazaeli and Fariba Ahmadizar and Maarten Leusink and Arets, {Hubertus G M} and Raaijmakers, {Jan A M} and Uiterwaal, {Cuno S P M} and {van der Ent}, {Cornelis K} and {Maitland-vd Zee}, Anke-Hilse and Vijverberg, {Susanne J H}",

note = "Publisher Copyright: {\textcopyright} 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.",

year = "2018",

month = feb,

doi = "10.1111/pai.12824",

language = "English",

volume = "29",

pages = "72--77",

journal = "Pediatric Allergy and Immunology",

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Arabkhazaeli, A, Ahmadizar, F, Leusink, M, Arets, HGM, Raaijmakers, JAM, Uiterwaal, CSPM, van der Ent, CK, Maitland-vd Zee, A-H & Vijverberg, SJH 2018, 'The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort', Pediatric Allergy and Immunology, vol. 29, no. 1, pp. 72-77. https://doi.org/10.1111/pai.12824

TY - JOUR

T1 - The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort

AU - Arabkhazaeli, Ali

AU - Ahmadizar, Fariba

AU - Leusink, Maarten

AU - Arets, Hubertus G M

AU - Raaijmakers, Jan A M

AU - Uiterwaal, Cuno S P M

AU - van der Ent, Cornelis K

AU - Maitland-vd Zee, Anke-Hilse

AU - Vijverberg, Susanne J H

PY - 2018/2

Y1 - 2018/2

N2 - BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. The GRS was tested in children who participated in a population-based newborn cohort (WHISTLER) and were followed from birth to school age. Logistic regression analysis was used to study the association between the GRS and the parental-reported allergies at age 5 (based on a reported allergy to ≥1 of the following allergens: pollen, house dust mites, or pets). A Cox regression model was used to study the association between GRS and a physician-diagnosed allergy during follow-up (allergic conjunctivitis, allergic rhinitis, and eczema/dermatitis). Cohen's kappa coefficient was calculated to study the agreement between physician-diagnosed allergy and parental-reported allergy at age 5.RESULTS: The GRS was significantly associated with parental-reported allergy (odds ratio: 15.9, 95% confidence interval (CI): 1.07-233.73) at age 5, as well as with a physician-diagnosed allergy during follow-up (hazard ratio: 1.89, 95% CI: 1.05-3.41). The overall agreement between physician-diagnosed and parental-reported allergies was 70.5% (kappa: 0.10, 95% CI: 0.03-0.18).CONCLUSIONS: An adult-derived GRS for allergy predicts the risk of developing allergies in childhood.

AB - BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children.METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults. The GRS was tested in children who participated in a population-based newborn cohort (WHISTLER) and were followed from birth to school age. Logistic regression analysis was used to study the association between the GRS and the parental-reported allergies at age 5 (based on a reported allergy to ≥1 of the following allergens: pollen, house dust mites, or pets). A Cox regression model was used to study the association between GRS and a physician-diagnosed allergy during follow-up (allergic conjunctivitis, allergic rhinitis, and eczema/dermatitis). Cohen's kappa coefficient was calculated to study the agreement between physician-diagnosed allergy and parental-reported allergy at age 5.RESULTS: The GRS was significantly associated with parental-reported allergy (odds ratio: 15.9, 95% confidence interval (CI): 1.07-233.73) at age 5, as well as with a physician-diagnosed allergy during follow-up (hazard ratio: 1.89, 95% CI: 1.05-3.41). The overall agreement between physician-diagnosed and parental-reported allergies was 70.5% (kappa: 0.10, 95% CI: 0.03-0.18).CONCLUSIONS: An adult-derived GRS for allergy predicts the risk of developing allergies in childhood.

KW - allergy

KW - birth cohort

KW - genetics

KW - risk score

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U2 - 10.1111/pai.12824

DO - 10.1111/pai.12824

M3 - Article

C2 - 29047167

SN - 0905-6157

VL - 29

SP - 72

EP - 77

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 1

ER -

The association between a genetic risk score for allergy and the risk of developing allergies in childhood—Results of the WHISTLER cohort

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