The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy

Z. J. van der Klooster; S. Sepehrkhouy; M. Harakalova; R. Goldschmeding; N. de Jonge; A. J. Suurmeijer; R. A. de Weger; F. W. Asselbergs; A. Vink

doi:10.1016/j.healun.2015.01.091

The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy

Z. J. van der Klooster, S. Sepehrkhouy, M. Harakalova, R. Goldschmeding, N. de Jonge, A. J. Suurmeijer, R. A. de Weger, F. W. Asselbergs, A. Vink

Research output: Contribution to journal › Meeting Abstract › Other research output

Abstract

Genetic dilated cardiomyopathy is a heterogenous group of diseases caused by mutations in various genes. Progressive cardiomyocyte loss and subsequent fibrosis is a key feature of this disease. Several types of cardiomyocyte cell death have been implicated: (macro) autophagy-related cell death, apoptosis, necroptosis and oncosis. One plausible mechanism of genetic cardiomyopathy is proteotoxicity of accumulated mutant protein aggregates. Here we investigate the association of such aggregates as a sign of autophagy-related cardiomyocyte cell death with specific pathogenic mutations in dilated cardiomyopathy.

Original language	English
Pages (from-to)	S38-S39
Number of pages	2
Journal	Journal of Heart and Lung Transplantation
Volume	34
Issue number	4, Suppl.
DOIs	https://doi.org/10.1016/j.healun.2015.01.091
Publication status	Published - Apr 2015
Event	35th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation - Nice, France Duration: 15 Apr 2015 → 18 Apr 2015

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van der Klooster, Z. J., Sepehrkhouy, S., Harakalova, M., Goldschmeding, R., de Jonge, N., Suurmeijer, A. J., de Weger, R. A., Asselbergs, F. W., & Vink, A. (2015). The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy. Journal of Heart and Lung Transplantation, 34(4, Suppl.), S38-S39. https://doi.org/10.1016/j.healun.2015.01.091

@article{d322b20143cd44d1860f15f3582cafb1,

title = "The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy",

abstract = "Genetic dilated cardiomyopathy is a heterogenous group of diseases caused by mutations in various genes. Progressive cardiomyocyte loss and subsequent fibrosis is a key feature of this disease. Several types of cardiomyocyte cell death have been implicated: (macro) autophagy-related cell death, apoptosis, necroptosis and oncosis. One plausible mechanism of genetic cardiomyopathy is proteotoxicity of accumulated mutant protein aggregates. Here we investigate the association of such aggregates as a sign of autophagy-related cardiomyocyte cell death with specific pathogenic mutations in dilated cardiomyopathy.",

author = "{van der Klooster}, {Z. J.} and S. Sepehrkhouy and M. Harakalova and R. Goldschmeding and {de Jonge}, N. and Suurmeijer, {A. J.} and {de Weger}, {R. A.} and Asselbergs, {F. W.} and A. Vink",

year = "2015",

month = apr,

doi = "10.1016/j.healun.2015.01.091",

language = "English",

volume = "34",

pages = "S38--S39",

journal = "Journal of Heart and Lung Transplantation",

issn = "1053-2498",

publisher = "Elsevier",

number = "4, Suppl.",

note = "35th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation ; Conference date: 15-04-2015 Through 18-04-2015",

}

van der Klooster, ZJ, Sepehrkhouy, S, Harakalova, M , Goldschmeding, R, de Jonge, N, Suurmeijer, AJ, de Weger, RA, Asselbergs, FW & Vink, A 2015, 'The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy', Journal of Heart and Lung Transplantation, vol. 34, no. 4, Suppl., pp. S38-S39. https://doi.org/10.1016/j.healun.2015.01.091

The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy. / van der Klooster, Z. J.; Sepehrkhouy, S.; Harakalova, M. et al.
In: Journal of Heart and Lung Transplantation, Vol. 34, No. 4, Suppl., 04.2015, p. S38-S39.

Research output: Contribution to journal › Meeting Abstract › Other research output

TY - JOUR

T1 - The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy

AU - van der Klooster, Z. J.

AU - Sepehrkhouy, S.

AU - Harakalova, M.

AU - Goldschmeding, R.

AU - de Jonge, N.

AU - Suurmeijer, A. J.

AU - de Weger, R. A.

AU - Asselbergs, F. W.

AU - Vink, A.

PY - 2015/4

Y1 - 2015/4

N2 - Genetic dilated cardiomyopathy is a heterogenous group of diseases caused by mutations in various genes. Progressive cardiomyocyte loss and subsequent fibrosis is a key feature of this disease. Several types of cardiomyocyte cell death have been implicated: (macro) autophagy-related cell death, apoptosis, necroptosis and oncosis. One plausible mechanism of genetic cardiomyopathy is proteotoxicity of accumulated mutant protein aggregates. Here we investigate the association of such aggregates as a sign of autophagy-related cardiomyocyte cell death with specific pathogenic mutations in dilated cardiomyopathy.

AB - Genetic dilated cardiomyopathy is a heterogenous group of diseases caused by mutations in various genes. Progressive cardiomyocyte loss and subsequent fibrosis is a key feature of this disease. Several types of cardiomyocyte cell death have been implicated: (macro) autophagy-related cell death, apoptosis, necroptosis and oncosis. One plausible mechanism of genetic cardiomyopathy is proteotoxicity of accumulated mutant protein aggregates. Here we investigate the association of such aggregates as a sign of autophagy-related cardiomyocyte cell death with specific pathogenic mutations in dilated cardiomyopathy.

U2 - 10.1016/j.healun.2015.01.091

DO - 10.1016/j.healun.2015.01.091

M3 - Meeting Abstract

SN - 1053-2498

VL - 34

SP - S38-S39

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 4, Suppl.

T2 - 35th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation

Y2 - 15 April 2015 through 18 April 2015

ER -

The Amount of Autophagy-Related Cardiomyocyte Cell Death Is Associated With the Type of Pathogenic Mutation in Genetic Dilated Cardiomyopathy

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