The Additional Value of Somatostatin Receptor Positron Emission Computed Tomography ([68Ga]Ga-DOTATOC PET/CT) Compared with Magnetic Resonance Imaging of the Head and Neck Region in Paraganglioma Patients: A Pilot Study

Carolijn J.M. de Bresser*, Bart Jeroen Petri, Arthur J.A.T. Braat, Bart de Keizer, Mark J.C. van Treijen, Jan Willem Dankbaar, Frank A. Pameijer, Marius G.J. Kok, Mischa de Ridder, Bernadette P.M. van Nesselrooij, Remco de Bree, Gert J. de Borst, Johannes A. Rijken

*Corresponding author for this work

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Abstract

The Dutch guideline for patients suspected of head and neck paragangliomas (HNPGLs) recommends magnetic resonance imaging (MRI) and/or computed tomography (CT) of the head and neck area. Additionally, it suggests considering additional nuclear imaging. The aim of this study was to evaluate the outcomes of [68Ga]Ga-DOTATOC PET/CT compared to MRI in patients with suspected HNPGLs and carriers of genetic variations. Methods: In this single-center pilot study, retrospective data were obtained from consecutive patients between 2016 and 2023. Both MRI and [68Ga]Ga-DOTATOC PET/CT were performed within 12 months. The primary outcome was the location of HNPGLs. Results: A total of 25 consecutive patients were included, and 7 patients (28.0%, p = 0.5) showed differences between the imaging modalities, of whom 5 patients had unexpected localizations with additional uptake by somatostatin receptors (SSTR) on the [68Ga]Ga-DOTATOC PET/CT. Conclusions: The authors recommend performing baseline imaging with [68Ga]Ga-DOTATOC PET/CT (if available) in variant carriers and using MRI/CT for follow-up according to the regional protocol, thereby shifting the gold standard for baseline imaging from MRI/CT to [68Ga]Ga-DOTATOC PET/CT.

Original languageEnglish
Article number986
Pages (from-to)1-9
Number of pages9
JournalCancers
Volume16
Issue number5
DOIs
Publication statusPublished - Mar 2024

Keywords

  • head and neck paraganglioma
  • MRI
  • [Ga]Ga-DOTATOC PET/CT

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