Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease

Nelleke Tolboom; Maqsood Yaqub; Ronald Boellaard; Gert Luurtsema; Albert D Windhorst; Philip Scheltens; Adriaan A Lammertsma; Bart N M van Berckel

doi:10.1007/s00259-009-1129-6

Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease

Nelleke Tolboom^*, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D Windhorst, Philip Scheltens, Adriaan A Lammertsma, Bart N M van Berckel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: The aim of this study was to assess the test-retest variability of [11C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.

METHODS: [11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.

RESULTS: Test-retest variability was best ( approximately 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ( approximately 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.

CONCLUSION: Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [11C]PIB PET studies.

Original language	English
Pages (from-to)	1629-1638
Number of pages	10
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	36
Issue number	10
DOIs	https://doi.org/10.1007/s00259-009-1129-6
Publication status	Published - Oct 2009
Externally published	Yes

Keywords

Aged
Alzheimer Disease/diagnostic imaging
Aniline Compounds
Benzothiazoles
Carbon Radioisotopes
Case-Control Studies
Cerebellum/diagnostic imaging
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography/methods
Radiopharmaceuticals
Reproducibility of Results
Thiazoles

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10.1007/s00259-009-1129-6

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title = "Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease",

abstract = "PURPOSE: The aim of this study was to assess the test-retest variability of [11C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.METHODS: [11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.RESULTS: Test-retest variability was best ( approximately 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ( approximately 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.CONCLUSION: Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [11C]PIB PET studies.",

keywords = "Aged, Alzheimer Disease/diagnostic imaging, Aniline Compounds, Benzothiazoles, Carbon Radioisotopes, Case-Control Studies, Cerebellum/diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography/methods, Radiopharmaceuticals, Reproducibility of Results, Thiazoles",

author = "Nelleke Tolboom and Maqsood Yaqub and Ronald Boellaard and Gert Luurtsema and Windhorst, {Albert D} and Philip Scheltens and Lammertsma, {Adriaan A} and {van Berckel}, {Bart N M}",

year = "2009",

month = oct,

doi = "10.1007/s00259-009-1129-6",

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AU - Tolboom, Nelleke

AU - Yaqub, Maqsood

AU - Boellaard, Ronald

AU - Luurtsema, Gert

AU - Windhorst, Albert D

AU - Scheltens, Philip

AU - Lammertsma, Adriaan A

AU - van Berckel, Bart N M

PY - 2009/10

Y1 - 2009/10

N2 - PURPOSE: The aim of this study was to assess the test-retest variability of [11C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.METHODS: [11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.RESULTS: Test-retest variability was best ( approximately 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ( approximately 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.CONCLUSION: Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [11C]PIB PET studies.

AB - PURPOSE: The aim of this study was to assess the test-retest variability of [11C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue.METHODS: [11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios.RESULTS: Test-retest variability was best ( approximately 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ( approximately 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls.CONCLUSION: Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [11C]PIB PET studies.

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KW - Alzheimer Disease/diagnostic imaging

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KW - Benzothiazoles

KW - Carbon Radioisotopes

KW - Case-Control Studies

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KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Positron-Emission Tomography/methods

KW - Radiopharmaceuticals

KW - Reproducibility of Results

KW - Thiazoles

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SN - 1619-7070

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JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 10

ER -

Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease

Abstract

Keywords

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