TEN-YEAR FOLLOW-UP STUDY OF ISLET-CELL ANTIBODIES AND CHILDHOOD DIABETES MELLITUS

G. J. Bruining; D. E. Grobbee; G. J. Scheffer; A. M. De Bruyn; J. L. Molenaar; A. Hofman; H. A. Bruining; H. A. Valkenburg

doi:10.1016/S0140-6736(89)92383-0

TEN-YEAR FOLLOW-UP STUDY OF ISLET-CELL ANTIBODIES AND CHILDHOOD DIABETES MELLITUS

G. J. Bruining^*, D. E. Grobbee, G. J. Scheffer, A. M. De Bruyn, J. L. Molenaar, A. Hofman, H. A. Bruining, H. A. Valkenburg

^*Corresponding author for this work

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Abstract

To find out whether subclinical autoimmunity precedes onset of non-familial insulin-dependent diabetes mellitus (IDDM), 4806 schoolchildren aged 5-19 years from a township in Holland were followed-up for at least ten years after blood was sampled for measurement of islet-cell antibodies (ICA). ICA positivity conferred a relative risk of IDDM of 533 (95% CI 145-1955). In the 10 years of follow-up 4 of the 8 ICA-positive subjects became insulin dependent, whereas the probability of being free of IDDM was 99·9% for those who were ICA-negative at the start of the study. The findings suggest that, although chronic autoimmunity involving the pancreatic beta-cells may precede non-familial IDDM by many years, a positive ICA test on a single occasion predicts the development of IDDM in only 4 out of 8 subjects over a period of 10 years.

Original language	English
Pages (from-to)	1100-1103
Number of pages	4
Journal	The Lancet
Volume	333
Issue number	8647
DOIs	https://doi.org/10.1016/S0140-6736(89)92383-0
Publication status	Published - 20 May 1989

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title = "TEN-YEAR FOLLOW-UP STUDY OF ISLET-CELL ANTIBODIES AND CHILDHOOD DIABETES MELLITUS",

abstract = "To find out whether subclinical autoimmunity precedes onset of non-familial insulin-dependent diabetes mellitus (IDDM), 4806 schoolchildren aged 5-19 years from a township in Holland were followed-up for at least ten years after blood was sampled for measurement of islet-cell antibodies (ICA). ICA positivity conferred a relative risk of IDDM of 533 (95% CI 145-1955). In the 10 years of follow-up 4 of the 8 ICA-positive subjects became insulin dependent, whereas the probability of being free of IDDM was 99·9% for those who were ICA-negative at the start of the study. The findings suggest that, although chronic autoimmunity involving the pancreatic beta-cells may precede non-familial IDDM by many years, a positive ICA test on a single occasion predicts the development of IDDM in only 4 out of 8 subjects over a period of 10 years.",

author = "Bruining, {G. J.} and Grobbee, {D. E.} and Scheffer, {G. J.} and {De Bruyn}, {A. M.} and Molenaar, {J. L.} and A. Hofman and Bruining, {H. A.} and Valkenburg, {H. A.}",

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AU - Bruining, G. J.

AU - Grobbee, D. E.

AU - Scheffer, G. J.

AU - De Bruyn, A. M.

AU - Molenaar, J. L.

AU - Hofman, A.

AU - Bruining, H. A.

AU - Valkenburg, H. A.

PY - 1989/5/20

Y1 - 1989/5/20

N2 - To find out whether subclinical autoimmunity precedes onset of non-familial insulin-dependent diabetes mellitus (IDDM), 4806 schoolchildren aged 5-19 years from a township in Holland were followed-up for at least ten years after blood was sampled for measurement of islet-cell antibodies (ICA). ICA positivity conferred a relative risk of IDDM of 533 (95% CI 145-1955). In the 10 years of follow-up 4 of the 8 ICA-positive subjects became insulin dependent, whereas the probability of being free of IDDM was 99·9% for those who were ICA-negative at the start of the study. The findings suggest that, although chronic autoimmunity involving the pancreatic beta-cells may precede non-familial IDDM by many years, a positive ICA test on a single occasion predicts the development of IDDM in only 4 out of 8 subjects over a period of 10 years.

AB - To find out whether subclinical autoimmunity precedes onset of non-familial insulin-dependent diabetes mellitus (IDDM), 4806 schoolchildren aged 5-19 years from a township in Holland were followed-up for at least ten years after blood was sampled for measurement of islet-cell antibodies (ICA). ICA positivity conferred a relative risk of IDDM of 533 (95% CI 145-1955). In the 10 years of follow-up 4 of the 8 ICA-positive subjects became insulin dependent, whereas the probability of being free of IDDM was 99·9% for those who were ICA-negative at the start of the study. The findings suggest that, although chronic autoimmunity involving the pancreatic beta-cells may precede non-familial IDDM by many years, a positive ICA test on a single occasion predicts the development of IDDM in only 4 out of 8 subjects over a period of 10 years.

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JF - The Lancet

IS - 8647

ER -

TEN-YEAR FOLLOW-UP STUDY OF ISLET-CELL ANTIBODIES AND CHILDHOOD DIABETES MELLITUS

Abstract

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