Telomere length and incident atrial fibrillation - data of the PREVEND cohort

Joylene E Siland; Bastiaan Geelhoed; Isabelle C van Gelder; Pim van der Harst; Michiel Rienstra

doi:10.1371/journal.pone.0171545

Telomere length and incident atrial fibrillation - data of the PREVEND cohort

Joylene E Siland, Bastiaan Geelhoed, Isabelle C van Gelder, Pim van der Harst, Michiel Rienstra

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.

METHODS: We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.

RESULTS: Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.

CONCLUSIONS: We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort.

Original language	English
Article number	e0171545
Pages (from-to)	e0171545
Journal	PLoS ONE
Volume	12
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0171545
Publication status	Published - Feb 2017
Externally published	Yes

Keywords

Age Factors
Atrial Fibrillation/epidemiology
Cohort Studies
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Risk Factors
Sex Factors
Telomere

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title = "Telomere length and incident atrial fibrillation - data of the PREVEND cohort",

abstract = "BACKGROUND: The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.METHODS: We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.RESULTS: Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.CONCLUSIONS: We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort.",

keywords = "Age Factors, Atrial Fibrillation/epidemiology, Cohort Studies, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Risk Factors, Sex Factors, Telomere",

author = "Siland, {Joylene E} and Bastiaan Geelhoed and {van Gelder}, {Isabelle C} and {van der Harst}, Pim and Michiel Rienstra",

note = "Funding Information: The PREVEND study is supported by the Dutch Kidney Foundation (grant E0.13), the National Institutes of Health (grant 2R01LM010098), The Netherlands organization for health research and development (NWO-Groot grant 175.010.2007.006, ZonMw grant 90.700.441), and the Dutch Inter University Cardiology Institute Netherlands (ICIN), and the Netherlands Heart Foundation (grant NHS2010B280). Dr. M. Rienstra is supported by a grant from the Netherlands Organization for Scientific Research (Veni grant 016.136.055). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2017 Siland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2017",

month = feb,

doi = "10.1371/journal.pone.0171545",

language = "English",

volume = "12",

pages = "e0171545",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

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TY - JOUR

T1 - Telomere length and incident atrial fibrillation - data of the PREVEND cohort

AU - Siland, Joylene E

AU - Geelhoed, Bastiaan

AU - van Gelder, Isabelle C

AU - van der Harst, Pim

AU - Rienstra, Michiel

N1 - Funding Information: The PREVEND study is supported by the Dutch Kidney Foundation (grant E0.13), the National Institutes of Health (grant 2R01LM010098), The Netherlands organization for health research and development (NWO-Groot grant 175.010.2007.006, ZonMw grant 90.700.441), and the Dutch Inter University Cardiology Institute Netherlands (ICIN), and the Netherlands Heart Foundation (grant NHS2010B280). Dr. M. Rienstra is supported by a grant from the Netherlands Organization for Scientific Research (Veni grant 016.136.055). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2017 Siland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2017/2

Y1 - 2017/2

N2 - BACKGROUND: The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.METHODS: We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.RESULTS: Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.CONCLUSIONS: We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort.

AB - BACKGROUND: The incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and Vascular End-stage Disease (PREVEND) study.METHODS: We included 7775 individuals without prevalent AF, and with leukocyte telomere length measured. Mean telomere length was determined by a monochrome multiplex quantitative polymerase chain reaction-based assay.RESULTS: Mean age of our cohort was 49±13 years, and 50% were men. During a mean follow-up of 11.4±2.9 years incident AF was detected in 367 (4.7%) individuals. Telomere length was shorter in individuals developing incident AF compared to those without AF (p = 0.013). Incident AF was inversely related to the telomere length. In the quartile with the longest telomere length 68 (3.5%) individuals developed AF, in the shortest telomere length quartile 100 (5.1%) individuals (p = 0.032). Telomere length was associated with incident AF in the second shortest telomere length quartile using the longest telomere length quartile as reference (hazard ratio 1.64; 95% CI 1.02-2.66; p = 0.043). After including age or AF risk factors, the relation between telomere length and incident AF was no longer significant. We found a significant interaction of age, male sex, systolic blood pressure, BMI, heart failure, and myocardial infarction with telomere length for the association with incident AF.CONCLUSIONS: We found that shorter leukocyte telomere length is not independently associated with incident AF in a community-based cohort.

KW - Age Factors

KW - Atrial Fibrillation/epidemiology

KW - Cohort Studies

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Sex Factors

KW - Telomere

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DO - 10.1371/journal.pone.0171545

M3 - Article

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SN - 1932-6203

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SP - e0171545

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - e0171545

ER -

Telomere length and incident atrial fibrillation - data of the PREVEND cohort

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Keywords

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