TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Trudy Straetemans; Anke Janssen; Koen Jansen; Ruud Doorn; Tineke Aarts; Anna D D van Muyden; Marieke Simonis; Judith Bergboer; Moniek de Witte; Zsolt Sebestyen; Jurgen Kuball

doi:10.1016/j.ymthe.2019.11.030

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Trudy Straetemans, Anke Janssen, Koen Jansen, Ruud Doorn, Tineke Aarts, Anna D D van Muyden, Marieke Simonis, Judith Bergboer, Moniek de Witte, Zsolt Sebestyen, Jurgen Kuball

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Straetemans and colleagues characterized αβT cells engineered to express a defined γδT cell receptor (TEG001) used in a first-in-human clinical study, with TLA in combination with NGS and qPCR. They provide a rapid strategy to evaluate the presence, integrity, and persistence of genetic information along the production chain of any GTMP.

Original language	English
Pages (from-to)	561-571
Number of pages	11
Journal	Molecular Therapy
Volume	28
Issue number	2
Early online date	14 Dec 2019
DOIs	https://doi.org/10.1016/j.ymthe.2019.11.030
Publication status	Published - 5 Feb 2020

Keywords

engineered T cells
gene therapy medicinal product
GTMP
targeted locus amplification
TEG001
TLA
vector copy number
γδT cells

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10.1016/j.ymthe.2019.11.030

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title = "TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product",

abstract = "Straetemans and colleagues characterized αβT cells engineered to express a defined γδT cell receptor (TEG001) used in a first-in-human clinical study, with TLA in combination with NGS and qPCR. They provide a rapid strategy to evaluate the presence, integrity, and persistence of genetic information along the production chain of any GTMP.",

keywords = "engineered T cells, gene therapy medicinal product, GTMP, targeted locus amplification, TEG001, TLA, vector copy number, γδT cells",

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T1 - TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

AU - Straetemans, Trudy

AU - Janssen, Anke

AU - Jansen, Koen

AU - Doorn, Ruud

AU - Aarts, Tineke

AU - van Muyden, Anna D D

AU - Simonis, Marieke

AU - Bergboer, Judith

AU - de Witte, Moniek

AU - Sebestyen, Zsolt

AU - Kuball, Jurgen

PY - 2020/2/5

Y1 - 2020/2/5

N2 - Straetemans and colleagues characterized αβT cells engineered to express a defined γδT cell receptor (TEG001) used in a first-in-human clinical study, with TLA in combination with NGS and qPCR. They provide a rapid strategy to evaluate the presence, integrity, and persistence of genetic information along the production chain of any GTMP.

AB - Straetemans and colleagues characterized αβT cells engineered to express a defined γδT cell receptor (TEG001) used in a first-in-human clinical study, with TLA in combination with NGS and qPCR. They provide a rapid strategy to evaluate the presence, integrity, and persistence of genetic information along the production chain of any GTMP.

KW - engineered T cells

KW - gene therapy medicinal product

KW - GTMP

KW - targeted locus amplification

KW - TEG001

KW - TLA

KW - vector copy number

KW - γδT cells

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DO - 10.1016/j.ymthe.2019.11.030

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SN - 1525-0016

VL - 28

SP - 561

EP - 571

JO - Molecular Therapy

JF - Molecular Therapy

IS - 2

ER -

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Abstract

Keywords

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