Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Geertruida J. van Woudenbergh; Anneleen Kuijsten; Dagmar Drogan; Daphne L. van der A; Dora Romaguera; Eva Ardanaz; Pilar Amiano; Aurelio Barricarte; Joline W. J. Beulens; Heiner Boeing; H. Bas Bueno-de-Mesquita; Christina C. Dahm; M-Doleres Chirlaque; Fran-coise Clavel; Francesca L. Crowe; Piia-Piret Eomois; Guy Fagher-azzi; Paul W. Franks; Jytte Halkjaer; Kay T. Khaw; Giovanna Masala; Amalia Mattiello; Peter Nilsson; Kim Overvad; J. Ramon Quiros; Olov Rolandsson; Isabelle Romieu; Carlotta Sacerdote; Maria-Jose Sanchez; Matthias B. Schulze; Nadia Slimani; Ivonne Sluijs; Annemieke M. W. Spijkerman; Giovanna Tagliabue; Birgit Teucher; Anne Tjonneland; Rosario Tumino; Nita G. Forouhi; Stephen Sharp; Claudia Langenberg; Edith J. M. Feskens; Elio Riboli; Nicholas J. Wareham

doi:10.1371/journal.pone.0036910

Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Geertruida J. van Woudenbergh^*, Anneleen Kuijsten, Dagmar Drogan, Daphne L. van der A, Dora Romaguera, Eva Ardanaz, Pilar Amiano, Aurelio Barricarte, Joline W. J. Beulens, Heiner Boeing, H. Bas Bueno-de-Mesquita, Christina C. Dahm, M-Doleres Chirlaque, Fran-coise Clavel, Francesca L. Crowe, Piia-Piret Eomois, Guy Fagher-azzi, Paul W. Franks, Jytte Halkjaer, Kay T. KhawGiovanna Masala, Amalia Mattiello, Peter Nilsson, Kim Overvad, J. Ramon Quiros, Olov Rolandsson, Isabelle Romieu, Carlotta Sacerdote, Maria-Jose Sanchez, Matthias B. Schulze, Nadia Slimani, Ivonne Sluijs, Annemieke M. W. Spijkerman, Giovanna Tagliabue, Birgit Teucher, Anne Tjonneland, Rosario Tumino, Nita G. Forouhi, Stephen Sharp, Claudia Langenberg, Edith J. M. Feskens, Elio Riboli, Nicholas J. Wareham,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.

Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-

Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.

Original language	English
Article number	36910
Number of pages	8
Journal	PLoS ONE [E]
Volume	7
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0036910
Publication status	Published - 30 May 2012

Keywords

BLACK TEA
GREEN TEA
OOLONG TEA
COFFEE
RISK
OBESITY
PLASMA
CANCER
MILK
METAANALYSIS

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10.1371/journal.pone.0036910

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van Woudenbergh, G. J., Kuijsten, A., Drogan, D., van der A, D. L., Romaguera, D., Ardanaz, E., Amiano, P., Barricarte, A., Beulens, J. W. J., Boeing, H., Bueno-de-Mesquita, H. B., Dahm, C. C., Chirlaque, M.-D., Clavel, F., Crowe, F. L., Eomois, P.-P., Fagher-azzi, G., Franks, P. W., Halkjaer, J. (2012). Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. PLoS ONE [E], 7(5), Article 36910. https://doi.org/10.1371/journal.pone.0036910

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title = "Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study",

abstract = "Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.",

keywords = "BLACK TEA, GREEN TEA, OOLONG TEA, COFFEE, RISK, OBESITY, PLASMA, CANCER, MILK, METAANALYSIS",

author = "{van Woudenbergh}, {Geertruida J.} and Anneleen Kuijsten and Dagmar Drogan and {van der A}, {Daphne L.} and Dora Romaguera and Eva Ardanaz and Pilar Amiano and Aurelio Barricarte and Beulens, {Joline W. J.} and Heiner Boeing and Bueno-de-Mesquita, {H. Bas} and Dahm, {Christina C.} and M-Doleres Chirlaque and Fran-coise Clavel and Crowe, {Francesca L.} and Piia-Piret Eomois and Guy Fagher-azzi and Franks, {Paul W.} and Jytte Halkjaer and Khaw, {Kay T.} and Giovanna Masala and Amalia Mattiello and Peter Nilsson and Kim Overvad and Quiros, {J. Ramon} and Olov Rolandsson and Isabelle Romieu and Carlotta Sacerdote and Maria-Jose Sanchez and Schulze, {Matthias B.} and Nadia Slimani and Ivonne Sluijs and Spijkerman, {Annemieke M. W.} and Giovanna Tagliabue and Birgit Teucher and Anne Tjonneland and Rosario Tumino and Forouhi, {Nita G.} and Stephen Sharp and Claudia Langenberg and Feskens, {Edith J. M.} and Elio Riboli and Wareham, {Nicholas J.}",

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language = "English",

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van Woudenbergh, GJ, Kuijsten, A, Drogan, D, van der A, DL, Romaguera, D, Ardanaz, E, Amiano, P, Barricarte, A, Beulens, JWJ, Boeing, H, Bueno-de-Mesquita, HB, Dahm, CC, Chirlaque, M-D, Clavel, F, Crowe, FL, Eomois, P-P, Fagher-azzi, G, Franks, PW, Halkjaer, J, Khaw, KT, Masala, G, Mattiello, A, Nilsson, P, Overvad, K, Quiros, JR, Rolandsson, O, Romieu, I, Sacerdote, C, Sanchez, M-J, Schulze, MB, Slimani, N, Sluijs, I, Spijkerman, AMW, Tagliabue, G, Teucher, B, Tjonneland, A, Tumino, R, Forouhi, NG, Sharp, S, Langenberg, C, Feskens, EJM, Riboli, E, Wareham, NJ 2012, 'Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study', PLoS ONE [E], vol. 7, no. 5, 36910. https://doi.org/10.1371/journal.pone.0036910

TY - JOUR

T1 - Tea Consumption and Incidence of Type 2 Diabetes in Europe

T2 - The EPIC-InterAct Case-Cohort Study

AU - van Woudenbergh, Geertruida J.

AU - Kuijsten, Anneleen

AU - Drogan, Dagmar

AU - van der A, Daphne L.

AU - Romaguera, Dora

AU - Ardanaz, Eva

AU - Amiano, Pilar

AU - Barricarte, Aurelio

AU - Beulens, Joline W. J.

AU - Boeing, Heiner

AU - Bueno-de-Mesquita, H. Bas

AU - Dahm, Christina C.

AU - Chirlaque, M-Doleres

AU - Clavel, Fran-coise

AU - Crowe, Francesca L.

AU - Eomois, Piia-Piret

AU - Fagher-azzi, Guy

AU - Franks, Paul W.

AU - Halkjaer, Jytte

AU - Khaw, Kay T.

AU - Masala, Giovanna

AU - Mattiello, Amalia

AU - Nilsson, Peter

AU - Overvad, Kim

AU - Quiros, J. Ramon

AU - Rolandsson, Olov

AU - Romieu, Isabelle

AU - Sacerdote, Carlotta

AU - Sanchez, Maria-Jose

AU - Schulze, Matthias B.

AU - Slimani, Nadia

AU - Sluijs, Ivonne

AU - Spijkerman, Annemieke M. W.

AU - Tagliabue, Giovanna

AU - Teucher, Birgit

AU - Tjonneland, Anne

AU - Tumino, Rosario

AU - Forouhi, Nita G.

AU - Sharp, Stephen

AU - Langenberg, Claudia

AU - Feskens, Edith J. M.

AU - Riboli, Elio

AU - Wareham, Nicholas J.

PY - 2012/5/30

Y1 - 2012/5/30

N2 - Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.

AB - Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.

KW - BLACK TEA

KW - GREEN TEA

KW - OOLONG TEA

KW - COFFEE

KW - RISK

KW - OBESITY

KW - PLASMA

KW - CANCER

KW - MILK

KW - METAANALYSIS

U2 - 10.1371/journal.pone.0036910

DO - 10.1371/journal.pone.0036910

M3 - Article

C2 - 22666334

SN - 1932-6203

VL - 7

JO - PLoS ONE [E]

JF - PLoS ONE [E]

IS - 5

M1 - 36910

ER -

Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Abstract

Keywords

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