Targeting the TLR4-MD2 axis in systemic sclerosis

Steven O'Reilly, Jacob M van Laar

Research output: Contribution to journalEditorialAcademicpeer-review

Abstract

Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

Original languageEnglish
Article numbere98850
Pages (from-to)564-566
Number of pages3
JournalNature Reviews. Rheumatology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Fibroblasts
  • Fibrosis
  • Humans
  • Lipopolysaccharides
  • Scleroderma, Systemic
  • Skin
  • Toll-Like Receptor 4

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