Targeting RNA helicases in cancer: The translation trap

Marise R. Heerma van Voss, Paul J. van Diest, Venu Raman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Cancer cells are reliant on the cellular translational machinery for both global elevation of protein synthesis and the translation of specific mRNAs that promote tumor cell survival. Targeting translational control in cancer is therefore increasingly recognized as a promising therapeutic strategy. In this regard, DEAD/H box RNA helicases are a very interesting group of proteins, with several family members regulating mRNA translation in cancer cells. In this review, we delineate the mechanisms by which DEAD/H box proteins modulate oncogenic translation and how inhibition of these RNA helicases can be exploited for anti-cancer therapeutics.

Original languageEnglish
Pages (from-to)510-520
Number of pages11
JournalBiochimica et Biophysica Acta-Reviews on Cancer
Issue number2
Publication statusPublished - 1 Dec 2017


  • DDX
  • DDX3
  • eIF4A
  • RNA helicase
  • Translation


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