Target Identification and Validation: Tissue Biobanks

W. Peeters*, F. L. Moll, R. J. Guzman, D. P V de Kleijn, G. Pasterkamp

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Tools, technical platforms and methods need to be wisely utilized to aid target identification and validation in translational processes. Amongst these, several -omics sciences have been established and constitute nowadays fields of their own. Such is the case of genomics, transcriptomics, proteomics, metabolomics, which address the genome, RNA, proteome and metabolome, respectively. Biobanks represent essential sources of information and pharmacogenetics helps to personalize drug developments early on. From such repositories and -omics research, valuable biomarkers can be derived, and consortial approaches are being used to facilitate this process. Modern biomedical research with the aim of translating research findings into novel therapies to benefit patients relies to a large extent on animal models of human pathophysiology. Ultimately, early human trials further humanize and corroborate drug targets and allow for translatability scoring to predict final success of translation.

Original languageEnglish
Title of host publicationPrinciples of Translational Science in Medicine
Subtitle of host publicationFrom Bench to Bedside
EditorsMartin Wehling
Number of pages8
EditionSecond edition
ISBN (Print)9780128007211, 9780128006870
Publication statusPublished - 7 Apr 2015


  • "Omics"
  • Animal models
  • Biobanks
  • Pharmacogenetics
  • Translatability assessment


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