T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation

Thomas Alderliesten; Jill B De Vis; Petra M A Lemmers; Frank van Bel; Manon J N L Benders; Jeroen Hendrikse; Esben T Petersen

doi:10.1016/j.neuroimage.2016.06.012

T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation

Thomas Alderliesten, Jill B De Vis, Petra M A Lemmers, Frank van Bel, Manon J N L Benders, Jeroen Hendrikse, Esben T Petersen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND AND AIM: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement.

MATERIALS AND METHODS: Tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers. These two measures were compared to SO2 that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2 that were obtained by arterial spin labelling and T2-TRIR, respectively.

RESULTS: SO2-T2-BIOS and SO2-NIRS had a mean bias of -4.0% (95% CI -21.3% to 13.3%). SvO2-T2-BIOS correlated with SO2-NIRS (R(2)=0.41, p=0.002) and SvO2-T2-TRIR (R(2)=0.87, p=0.002). In addition, SO2-NIRS correlated with SvO2-T2-TRIR (R(2)=0.85, p=0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS (R(2)=0.21, p=0.04), but was not significant in relation to SO2-NIRS.

DISCUSSION/CONCLUSION: Full brain SO2 assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T2-BIOS provides confidence in measuring cerebral SO2 by either technique. As it stands now, the T2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2 assessment.

Original language	English
Pages (from-to)	65-73
Number of pages	9
Journal	NeuroImage
Volume	139
DOIs	https://doi.org/10.1016/j.neuroimage.2016.06.012
Publication status	Published - 9 Jun 2016

Keywords

Near-Infrared Spectroscopy;

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10.1016/j.neuroimage.2016.06.012

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@article{7fafe505ec454a669524b0f8e7451142,

title = "T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation",

abstract = "BACKGROUND AND AIM: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The {"}modified T2-prepared Blood Imaging of Oxygen Saturation{"} (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement.MATERIALS AND METHODS: Tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers. These two measures were compared to SO2 that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2 that were obtained by arterial spin labelling and T2-TRIR, respectively.RESULTS: SO2-T2-BIOS and SO2-NIRS had a mean bias of -4.0% (95% CI -21.3% to 13.3%). SvO2-T2-BIOS correlated with SO2-NIRS (R(2)=0.41, p=0.002) and SvO2-T2-TRIR (R(2)=0.87, p=0.002). In addition, SO2-NIRS correlated with SvO2-T2-TRIR (R(2)=0.85, p=0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS (R(2)=0.21, p=0.04), but was not significant in relation to SO2-NIRS.DISCUSSION/CONCLUSION: Full brain SO2 assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T2-BIOS provides confidence in measuring cerebral SO2 by either technique. As it stands now, the T2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2 assessment.",

keywords = "Near-Infrared Spectroscopy; ",

author = "Thomas Alderliesten and {De Vis}, {Jill B} and Lemmers, {Petra M A} and {van Bel}, Frank and Benders, {Manon J N L} and Jeroen Hendrikse and Petersen, {Esben T}",

note = "Copyright {\textcopyright} 2016. Published by Elsevier Inc.",

year = "2016",

month = jun,

day = "9",

doi = "10.1016/j.neuroimage.2016.06.012",

language = "English",

volume = "139",

pages = "65--73",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - T2-prepared velocity selective labelling

T2 - A novel idea for full-brain mapping of oxygen saturation

AU - Alderliesten, Thomas

AU - De Vis, Jill B

AU - Lemmers, Petra M A

AU - van Bel, Frank

AU - Benders, Manon J N L

AU - Hendrikse, Jeroen

AU - Petersen, Esben T

PY - 2016/6/9

Y1 - 2016/6/9

N2 - BACKGROUND AND AIM: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement.MATERIALS AND METHODS: Tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers. These two measures were compared to SO2 that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2 that were obtained by arterial spin labelling and T2-TRIR, respectively.RESULTS: SO2-T2-BIOS and SO2-NIRS had a mean bias of -4.0% (95% CI -21.3% to 13.3%). SvO2-T2-BIOS correlated with SO2-NIRS (R(2)=0.41, p=0.002) and SvO2-T2-TRIR (R(2)=0.87, p=0.002). In addition, SO2-NIRS correlated with SvO2-T2-TRIR (R(2)=0.85, p=0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS (R(2)=0.21, p=0.04), but was not significant in relation to SO2-NIRS.DISCUSSION/CONCLUSION: Full brain SO2 assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T2-BIOS provides confidence in measuring cerebral SO2 by either technique. As it stands now, the T2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2 assessment.

AB - BACKGROUND AND AIM: Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2 is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2 measurement.MATERIALS AND METHODS: Tissue SO2, and venous SO2 (SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers. These two measures were compared to SO2 that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2 that were obtained by arterial spin labelling and T2-TRIR, respectively.RESULTS: SO2-T2-BIOS and SO2-NIRS had a mean bias of -4.0% (95% CI -21.3% to 13.3%). SvO2-T2-BIOS correlated with SO2-NIRS (R(2)=0.41, p=0.002) and SvO2-T2-TRIR (R(2)=0.87, p=0.002). In addition, SO2-NIRS correlated with SvO2-T2-TRIR (R(2)=0.85, p=0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS (R(2)=0.21, p=0.04), but was not significant in relation to SO2-NIRS.DISCUSSION/CONCLUSION: Full brain SO2 assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T2-BIOS provides confidence in measuring cerebral SO2 by either technique. As it stands now, the T2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2 assessment.

KW - Near-Infrared Spectroscopy;

U2 - 10.1016/j.neuroimage.2016.06.012

DO - 10.1016/j.neuroimage.2016.06.012

M3 - Article

C2 - 27291495

SN - 1053-8119

VL - 139

SP - 65

EP - 73

JO - NeuroImage

JF - NeuroImage

ER -

T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation

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Keywords

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