T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction

V Floré; P Claus; M A Vos; B Vandenberk; S Van Soest; K R Sipido; T Adriaenssens; J Bogaert; W Desmet; R Willems

doi:10.1007/s12265-015-9649-x

T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction

V Floré, P Claus, M A Vos, B Vandenberk, S Van Soest, K R Sipido, T Adriaenssens, J Bogaert, W Desmet, R Willems

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The purpose of this study is to investigate the relationship between T-wave alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During follow-up (3.5 ± 0.5 years), death (n = 2), ventricular tachycardia (n = 3), supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent coronary ischemia (n = 25) were observed. After multivariate analysis, positive TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) were associated with recurrent angina or ACS. Presence of MVO was correlated with TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The presence of MVO and TWA 1-12 months after STEMI is related to each other and to recurrent angina or ACS.

Original language	English
Pages (from-to)	484-492
Number of pages	9
Journal	Journal of Cardiovascular Translational Research
Volume	8
Issue number	8
DOIs	https://doi.org/10.1007/s12265-015-9649-x
Publication status	Published - Nov 2015

Keywords

Cardiac magnetic resonance imaging
Microvascular obstruction
Non-invasive risk stratification
ST segment elevation myocardial infarction
t-wave alternans

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10.1007/s12265-015-9649-x

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Floré, V., Claus, P., Vos, M. A., Vandenberk, B., Van Soest, S., Sipido, K. R., Adriaenssens, T., Bogaert, J., Desmet, W., & Willems, R. (2015). T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction. Journal of Cardiovascular Translational Research, 8(8), 484-492. https://doi.org/10.1007/s12265-015-9649-x

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title = "T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction",

abstract = "The purpose of this study is to investigate the relationship between T-wave alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During follow-up (3.5 ± 0.5 years), death (n = 2), ventricular tachycardia (n = 3), supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent coronary ischemia (n = 25) were observed. After multivariate analysis, positive TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) were associated with recurrent angina or ACS. Presence of MVO was correlated with TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The presence of MVO and TWA 1-12 months after STEMI is related to each other and to recurrent angina or ACS.",

keywords = "Cardiac magnetic resonance imaging, Microvascular obstruction, Non-invasive risk stratification, ST segment elevation myocardial infarction, t-wave alternans",

author = "V Flor{\'e} and P Claus and Vos, {M A} and B Vandenberk and {Van Soest}, S and Sipido, {K R} and T Adriaenssens and J Bogaert and W Desmet and R Willems",

year = "2015",

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doi = "10.1007/s12265-015-9649-x",

language = "English",

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Floré, V, Claus, P, Vos, MA, Vandenberk, B, Van Soest, S, Sipido, KR, Adriaenssens, T, Bogaert, J, Desmet, W & Willems, R 2015, 'T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction', Journal of Cardiovascular Translational Research, vol. 8, no. 8, pp. 484-492. https://doi.org/10.1007/s12265-015-9649-x

TY - JOUR

T1 - T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction

AU - Floré, V

AU - Claus, P

AU - Vos, M A

AU - Vandenberk, B

AU - Van Soest, S

AU - Sipido, K R

AU - Adriaenssens, T

AU - Bogaert, J

AU - Desmet, W

AU - Willems, R

PY - 2015/11

Y1 - 2015/11

N2 - The purpose of this study is to investigate the relationship between T-wave alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During follow-up (3.5 ± 0.5 years), death (n = 2), ventricular tachycardia (n = 3), supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent coronary ischemia (n = 25) were observed. After multivariate analysis, positive TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) were associated with recurrent angina or ACS. Presence of MVO was correlated with TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The presence of MVO and TWA 1-12 months after STEMI is related to each other and to recurrent angina or ACS.

AB - The purpose of this study is to investigate the relationship between T-wave alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During follow-up (3.5 ± 0.5 years), death (n = 2), ventricular tachycardia (n = 3), supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent coronary ischemia (n = 25) were observed. After multivariate analysis, positive TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) were associated with recurrent angina or ACS. Presence of MVO was correlated with TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The presence of MVO and TWA 1-12 months after STEMI is related to each other and to recurrent angina or ACS.

KW - Cardiac magnetic resonance imaging

KW - Microvascular obstruction

KW - Non-invasive risk stratification

KW - ST segment elevation myocardial infarction

KW - t-wave alternans

U2 - 10.1007/s12265-015-9649-x

DO - 10.1007/s12265-015-9649-x

M3 - Article

C2 - 26350221

SN - 1937-5387

VL - 8

SP - 484

EP - 492

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 8

ER -

T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary Ischemia After Myocardial Infarction

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Keywords

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