T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovani.

A. Hailu, D. van Baarle, G.J. Knol, N. Berhe, F. Miedema, P.A. Kager

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Abstract

During an epidemiological study of visceral leishmaniasis (VL) in south-west Ethiopia, 33 VL patients, 9 treated VL patients, 14 individuals with sub-clinical infection, 34 individuals with asymptomatic infection, and 19 healthy controls were studied for T cell subsets and cytokine profiles. Negative leishmanin skin test, CD3 and CD4 lymphocytopenia, and significantly reduced numbers of memory CD4+ T cells were found in VL patients compared to treated VL patients or persons with self-limiting asymptomatic infection. The proportion of CD4+ and CD8+ T cells that produced IFN-γ and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls. Plasma concentrations of IFN-γ and IL-10 were elevated in VL.
Original languageEnglish
Pages (from-to)182-191
Number of pages10
JournalClinical Immunology
Volume117
Issue number2
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Visceral leishmaniasis
  • Cytokines
  • Ethiopia
  • Asymptomatic
  • T cell subsets

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