T cell priming by tissue-derived dendritic cells: new insights from recent murine studies.

FCM Sille; A Visser; M Boes

doi:10.1016/j.cellimm.2005.10.004

T cell priming by tissue-derived dendritic cells: new insights from recent murine studies.

FCM Sille, A Visser, M Boes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

Original language	English
Pages (from-to)	77-85
Number of pages	9
Journal	Cellular Immunology
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/j.cellimm.2005.10.004
Publication status	Published - 1 Oct 2005

Keywords

DC migration
DC subsets
T cell priming
EPIDERMAL LANGERHANS CELLS
REGULATE ANTIGEN PRESENTATION
TUMOR-NECROSIS-FACTOR
REGIONAL LYMPH-NODES
MHC CLASS-I
HIGH ENDOTHELIAL VENULES
STEADY-STATE CONDITIONS
LEISHMANIA-MAJOR
CHEMOKINE RECEPTOR
CUTTING EDGE

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title = "T cell priming by tissue-derived dendritic cells: new insights from recent murine studies.",

abstract = "Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.",

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author = "FCM Sille and A Visser and M Boes",

year = "2005",

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doi = "10.1016/j.cellimm.2005.10.004",

language = "English",

volume = "237",

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T1 - T cell priming by tissue-derived dendritic cells: new insights from recent murine studies.

AU - Sille, FCM

AU - Visser, A

AU - Boes, M

PY - 2005/10/1

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N2 - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

AB - Dendritic cells (DCs) act as sentinels in peripheral tissues, continuously scavenging for antigens in their immediate surroundings. Their involvement in T cell responses is generally thought to consist of a linear progression of events, starting with capture of antigen in peripheral tissues such as the skin followed by migration to draining lymphoid organs and MHC-restricted presentation of antigen-derived peptide to induce T cell priming. The role of tissue-derived DCs in the direct priming of immune responses has lately been challenged. It now appears that, at least in some instances, a non-migratory subtype of DCs in the secondary lymphoid tissue presents tissue-derived antigen to T cells. Here, we review recent developments in research on DC function in the priming of immune responses.

KW - DC migration

KW - DC subsets

KW - T cell priming

KW - EPIDERMAL LANGERHANS CELLS

KW - REGULATE ANTIGEN PRESENTATION

KW - TUMOR-NECROSIS-FACTOR

KW - REGIONAL LYMPH-NODES

KW - MHC CLASS-I

KW - HIGH ENDOTHELIAL VENULES

KW - STEADY-STATE CONDITIONS

KW - LEISHMANIA-MAJOR

KW - CHEMOKINE RECEPTOR

KW - CUTTING EDGE

U2 - 10.1016/j.cellimm.2005.10.004

DO - 10.1016/j.cellimm.2005.10.004

M3 - Article

C2 - 16360134

SN - 0008-8749

VL - 237

SP - 77

EP - 85

JO - Cellular Immunology

JF - Cellular Immunology

IS - 2

ER -

T cell priming by tissue-derived dendritic cells: new insights from recent murine studies.

Abstract

Keywords

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