Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Lucas J T Kaaij; Robin H van der Weide; René F Ketting; Elzo de Wit

doi:10.1016/j.celrep.2018.06.003

Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Lucas J T Kaaij
, Robin H van der Weide
, René F Ketting^*
, Elzo de Wit^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.

Original language	English
Pages (from-to)	1-10.e4
Journal	Cell Reports
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2018.06.003
Publication status	Published - 3 Jul 2018
Externally published	Yes

Keywords

Animals
Chromatin/metabolism
Embryonic Development/genetics
Enhancer Elements, Genetic/genetics
Epigenomics
Genome
Histone Code
Zebrafish/embryology

Access to Document

10.1016/j.celrep.2018.06.003

Cite this

@article{54673dda119b41349312207881620377,

title = "Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development",

abstract = "How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.",

keywords = "Animals, Chromatin/metabolism, Embryonic Development/genetics, Enhancer Elements, Genetic/genetics, Epigenomics, Genome, Histone Code, Zebrafish/embryology",

author = "Kaaij, \{Lucas J T\} and \{van der Weide\}, \{Robin H\} and Ketting, \{Ren{\'e} F\} and \{de Wit\}, Elzo",

year = "2018",

month = jul,

day = "3",

doi = "10.1016/j.celrep.2018.06.003",

language = "English",

volume = "24",

pages = "1--10.e4",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

AU - Kaaij, Lucas J T

AU - van der Weide, Robin H

AU - Ketting, René F

AU - de Wit, Elzo

PY - 2018/7/3

Y1 - 2018/7/3

N2 - How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.

AB - How do developing zebrafish embryos organize their genome? Kaaij et al. show that, early in development, when there is no transcription, the genome is highly structured; however, when the zygotic genome is activated, this organization is lost. Later in development, the genome again adopts a structured organization.

KW - Animals

KW - Chromatin/metabolism

KW - Embryonic Development/genetics

KW - Enhancer Elements, Genetic/genetics

KW - Epigenomics

KW - Genome

KW - Histone Code

KW - Zebrafish/embryology

UR - https://www.scopus.com/pages/publications/85048898368

U2 - 10.1016/j.celrep.2018.06.003

DO - 10.1016/j.celrep.2018.06.003

M3 - Article

C2 - 29972771

SN - 2211-1247

VL - 24

SP - 1-10.e4

JO - Cell Reports

JF - Cell Reports

IS - 1

ER -

Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this